Tioguanine (redirect from 6-Thioguanine)
Tioguanine, also known as thioguanine or 6-thioguanine (6-TG) or tabloid is a medication used to treat acute myeloid leukemia (AML), acute lymphocytic...
20 KB (1,961 words) - 19:45, 22 September 2024
analogues subclass of antimetabolites family of medications. It works via 6-thioguanine to disrupt the making of RNA and DNA by cells. Azathioprine was first...
54 KB (5,490 words) - 15:52, 22 September 2024
bromodeoxyuridine (BrdU) and a cell lacking HGPRT is resistant to 6-thioguanine (6-TG) and 8-azaguanine. Thus, selection with one of the latter two drugs...
5 KB (638 words) - 02:17, 12 May 2024
Mercaptopurine (redirect from 6-mercaptopurine)
deoxythioguanosine. Some mercaptopurine is converted to nucleotide derivatives of 6-thioguanine (6-TG) by the sequential actions of inosinate (IMP) dehydrogenase and...
26 KB (2,647 words) - 17:55, 13 October 2024
that are used to treat one or more types of leukemia, include: 6-Mercaptopurine 6-Thioguanine Arsenic trioxide Asparaginase Cladribine Clofarabine Cyclophosphamide...
1 KB (70 words) - 18:51, 14 November 2023
mouse BALB/c strain. 4T1 cells are epithelial and are resistant to 6-thioguanine. In preclinical research, 4T1 cells have been used to study breast cancer...
7 KB (780 words) - 00:29, 6 July 2023
providing 6-thioguanine to a subject having said immune-mediated gastrointestinal disorder; and (b) determining the level of 6-thioguanine in said subject...
33 KB (3,847 words) - 17:03, 8 June 2024
Such systems include the HPRT assay for resistance to 8-azaguanine or 6-thioguanine, and ouabain-resistance (OUA) assay. Rat primary hepatocytes may also...
52 KB (6,017 words) - 05:31, 27 September 2024
mutation testing, it may be appropriate to grow her lymphocytes in 6-thioguanine (a purine analogue), which allows only HGPRT-deficient cells to survive...
38 KB (4,775 words) - 16:51, 5 September 2024
olaparib. Combining these newer medicines with older agents such as 6-Thioguanine (6TG) may overcome the resistance that can arise in BRCA cancers to...
92 KB (9,503 words) - 14:29, 12 August 2024
in poor-risk AML patients. The addition of 6-thioguanine gave rise to the DAT regimen, and the addition of 6-mercaptopurine gave rise to the DAM regimen...
4 KB (472 words) - 02:59, 5 June 2022
Hitchings, George H. (1955). "The Synthesis of 6-Thioguanine". Journal of the American Chemical Society. 77 (6): 1676. doi:10.1021/ja01611a082. In 1988 Elion...
25 KB (2,420 words) - 06:21, 8 October 2024
nanocrystals with 6-thioguanine: monitoring of drug delivery. Applied Nanoscience, 10 (1), 83–93. doi: 10.1007/s13204-019-01101-6. Zrazhevskiy, P., Sena...
38 KB (5,293 words) - 21:37, 21 December 2023
changed the nature of patent law in the United States. 6-Mercaptopurine (6-MP) 6-Thioguanine (6-TG) Azathioprine (AZA) Sahasranaman S, Howard D, Roy S...
2 KB (166 words) - 08:09, 24 December 2023
Thiopurine methyltransferase (category Genes on human chromosome 6)
metabolism of the thiopurine drugs such as azathioprine, 6-mercaptopurine and 6-thioguanine. TPMT catalyzes the S-methylation of thiopurine drugs. Defects...
13 KB (1,462 words) - 19:42, 22 September 2024
Weiren, Xu; Chengbu, Liu (May 2004). "Theoretical study of incorporating 6-thioguanine into a guanine tetrad and their influence on the metal ion guanine tetrad"...
8 KB (723 words) - 21:18, 20 March 2024
participates in the S-methylation of thiopurine drugs, which include 6-mercaptopurine, 6-thioguanine, and Azathioprine. The first two drugs are indicated for leukemias...
36 KB (4,062 words) - 21:54, 14 September 2024
structure of metabolic purines. Nucleobase analogues Thiopurines such as thioguanine are used to treat acute leukemias and remissions in acute granulocytic...
2 KB (186 words) - 01:57, 24 June 2022
ranitidine for gastroesophageal reflux disorder, mercaptopurine and thioguanine for the treatment of leukemia, allopurinol for gout, pyrimethamine for...
136 KB (12,275 words) - 14:36, 8 November 2024
new drug therapies for malaria (pyrimethamine), leukemia (6-mercaptopurine and thioguanine), gout (allopurinol), organ transplantation (azathioprine)...
9 KB (853 words) - 09:01, 13 September 2024
(June 2010). "Childhood leukemia". Pediatrics in Review. 31 (6): 234–41. doi:10.1542/pir.31-6-234. PMID 20516235. S2CID 207170780. "Prognosis and survival...
78 KB (7,755 words) - 17:38, 17 September 2024
139-65-1 Thiodicarb 59669-26-0 Thioguanine 154-42-7 Thiophanate methyl 23564-05-8 2-Thiouracil 141-90-2 Thiourea 62-56-6 Thorium dioxide 1314-20-1 Tobacco...
48 KB (211 words) - 18:08, 25 April 2024
nelarabine, cladribine, clofarabine, and pentostatin. The thiopurines include thioguanine and mercaptopurine. Anti-microtubule agents are plant-derived chemicals...
155 KB (17,518 words) - 23:36, 26 October 2024
(Ifex) (1988) Antimetabolites Mercaptopurine (1953) Methotrexate (1953) Thioguanine (1966) Cytosine arabinoside (Ara-C) (1969) Floxuridine (FUDR) (1970)...
33 KB (2,732 words) - 17:32, 25 October 2024
response to 2,2-anhydro-1-B-D-arabinofuranosyl-5-fluorocytosine and thioguanine on the L-12 protocol. In: Cancer. 1981 Nov 15;48(10), S. 2136–2142. PMID 6170414...
20 KB (2,664 words) - 05:42, 14 February 2024
protein provides resistance to thiopurine anticancer drugs, 6-mercaptopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine...
10 KB (1,385 words) - 01:54, 12 February 2024
University Calendar. Edinburgh: James Thin. 1888–1889. p. 421. Hart, Ernest, ed. (6 July 1889). "Edinburgh". British Medical Journal. II (1488). London: 343....
46 KB (2,126 words) - 22:15, 20 August 2024
available for use in clinical practice include markers for irinotecan, thioguanine, warfarin and 5FU. Toxgnostic studies are defined by four key elements:...
7 KB (950 words) - 22:42, 16 December 2021
938 – xanthine MeSH D03.438.759.794 – saxitoxin MeSH D03.438.759.854 – thioguanine MeSH D03.438.772.500 – monocrotaline MeSH D03.438.786.430 – ketanserin...
109 KB (10,094 words) - 16:51, 9 February 2024