Aptamers are oligomers of artificial ssDNA, RNA, XNA, or peptide that bind a specific target molecule, or family of target molecules. They exhibit a range...
60 KB (6,559 words) - 14:38, 19 June 2024
Aptamers, single-stranded RNA and DNA sequences, bind to an analyte and change their conformation. They function as nucleic acids selectively binding molecules...
28 KB (3,457 words) - 15:02, 20 October 2024
synthetically derived RNA aptamer born out of the need for a way of studying the role of RNAs at the cellular level. This aptamer was created using Systematic...
5 KB (637 words) - 13:11, 4 October 2023
RNA therapeutics (section RNA aptamers)
messenger RNA (mRNA), antisense RNA (asRNA), RNA interference (RNAi), and RNA aptamers. Of the four types, mRNA-based therapy is the only type which is based...
77 KB (8,886 words) - 09:03, 10 June 2024
Systematic evolution of ligands by exponential enrichment (section SELEX variants and alternative aptamer selection methods)
ligands. These single-stranded DNA or RNA are commonly referred to as aptamers. Although SELEX has emerged as the most commonly used name for the procedure...
41 KB (4,747 words) - 07:12, 9 October 2024
Anti-thrombin aptamers are G-quadruplex-bearing oligonucleotides, which recognizes the exosites of human thrombin. The first anti-thrombin aptamer, TBA, was...
23 KB (2,660 words) - 05:35, 3 June 2024
immuno-RCA, the ssDNA RCA primer can be conjugated to the 3' end of a DNA aptamer as well. The primer tail can be amplified through rolling circle amplification...
24 KB (2,920 words) - 14:34, 16 July 2024
international nonproprietary name is Rovunaptabin, is an oligonucleotide aptamer, a synthetic DNA compound designed to bind other chemicals. BC-007 is in...
17 KB (1,148 words) - 17:38, 23 July 2024
Smart ligand (redirect from Smart aptamers)
Known examples of smart ligands include DNA smart aptamers; however, RNA and peptide smart aptamers can also be developed. Smart ligands can find a set...
4 KB (390 words) - 03:56, 27 December 2023
alongside Paul Weiss and Anne M. Andrews. Her doctoral research considered aptamer-functionalised field effect transistors for serotonin and dopamine sensing...
6 KB (649 words) - 08:46, 20 February 2024
pair to DNA aptamer generation by in vitro selection (SELEX) and demonstrated the genetic alphabet expansion significantly augment DNA aptamer affinities...
32 KB (3,701 words) - 21:51, 25 October 2024
An L-ribonucleic acid aptamer (L-RNA aptamer, trade name Spiegelmer) is an RNA-like molecule built from L-ribose units. It is an artificial oligonucleotide...
6 KB (635 words) - 10:43, 7 September 2021
green. For example, Zhao et al., demonstrated the use of malachite green aptamer in microcantilever based sensors to detect low concentration of malachite...
18 KB (1,769 words) - 06:56, 28 June 2024
Melting: A Love Story 2010 Chemistry Maureen McKeague Selection of a DNA Aptamer for Homocysteine using SELEX 2009 Graduate Student Sue Lynn Lau The Role...
22 KB (2,451 words) - 22:41, 30 March 2024
usually consist of two metabolite-binding aptamer domains with similar structures in tandem. The aptamers were originally thought to cooperatively bind...
4 KB (443 words) - 20:38, 4 August 2024
an aptamer rather than an antibody. This could be seen as similar to a Southern blot, however the interaction is between a DNA molecule (the aptamer) and...
18 KB (2,101 words) - 01:17, 22 June 2024
increased scalability and consistency in manufacture compared to standard aptamer molecules. Optimer ligands are composed of single-stranded DNA or RNA polymers...
16 KB (1,551 words) - 23:22, 10 December 2023
linker synthesized with an alpha-1,3-gal-gal bond on one end and a DNA aptamer devised to bind specifically to the strain of influenza you have on the...
47 KB (4,855 words) - 20:31, 28 September 2024
IL-1α and the aptamer. Huang et al. uses ACE to investigate protein-protein interactions using aptamers. A α-thrombin binding aptamer was labeled with...
36 KB (4,675 words) - 21:03, 7 June 2024
and streptavidin proteins. DNA and other nucleic acids are the basis of aptamers, synthetic oligonucleotide ligands for specific target molecules used in...
166 KB (17,843 words) - 13:16, 19 September 2024
important for aptamer generation. Citartan, Marimuthu; et al. (December 2011). "Asymmetric PCR for good quality ssDNA generation towards DNA aptamer production"...
3 KB (334 words) - 20:53, 13 September 2023
its aptamer, which forms as many as five base-paired substructures. PreQ1-III riboswitch has a distinct structure and is also larger in aptamer size...
19 KB (2,058 words) - 23:58, 30 June 2024
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:...
31 KB (3,428 words) - 18:05, 24 October 2024
specifically bind antigens. They consist of artificial peptides or proteins, or aptamer-based nucleic acid molecules with a molar mass of about 3 to 20 kDa. Antibody...
119 KB (13,400 words) - 17:29, 29 August 2024
2014). "Intracellular gene transcription factor protein-guided MRI by DNA aptamers in vivo". FASEB Journal. 28 (1): 464–73. doi:10.1096/fj.13-234229. PMC 3868842...
92 KB (10,708 words) - 09:03, 25 September 2024
known different activity depending on enantiomeric form, Aptamers (L-ribonucleic acid aptamers): "That makes mirror-image biochemistry a potentially lucrative...
14 KB (1,604 words) - 18:14, 23 May 2024
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:...
92 KB (8,729 words) - 10:30, 16 October 2024
ASP-6294 Fasinumab Frunevetmab Fulranumab MEDI-578 Ranevetmab Tanezumab Aptamers: Against NGF: RBM-004 Decoy receptors: LEVI-04 (p75NTR-Fc) PDGF Agonists:...
42 KB (3,935 words) - 04:01, 30 April 2024
Novartis purchased the rights to market Ophthotech's Fovista (an anti-PDGF aptamer, also being investigated for use in combination with anti-VEGF treatments)...
144 KB (12,145 words) - 21:14, 28 September 2024
12-dimethylbenzanthracene), a mutagen. Moreover, HSF1 inhibition by a potent RNA aptamer attenuates mitogenic (MAPK) signaling and induces cancer cell apoptosis...
49 KB (5,533 words) - 10:41, 19 July 2024