Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products...
102 KB (11,438 words) - 12:54, 17 November 2024
example of attenuation used in many introductory genetics textbooks, is ribosome-mediated attenuation of the trp operon. Ribosome-mediated attenuation of the...
17 KB (2,242 words) - 19:56, 17 August 2024
Trp operon (category Gene expression)
concentration whereas the attenuation responds to the concentration of charged tRNAtrp. Thus, the trpR repressor decreases gene expression by altering the initiation...
21 KB (2,621 words) - 09:12, 8 January 2025
Heterologous expression refers to the expression of a gene or part of a gene in a host organism that does not naturally have the gene or gene fragment in...
45 KB (5,772 words) - 12:22, 17 January 2025
who contributed to the establishment of the one gene-one enzyme hypothesis and discovered attenuation, a riboswitch mechanism in which messenger RNA changes...
12 KB (1,119 words) - 20:25, 25 December 2024
(CRISPRa) is a gene regulation technique that utilizes an engineered form of the CRISPR-Cas9 system to enhance the expression of specific genes without altering...
22 KB (2,739 words) - 07:27, 29 September 2024
Transcription-translation coupling (category Gene expression)
Ribosome-mediated attenuation is a gene expression mechanism in which a transcriptional termination signal is regulated by translation. Attenuation occurs at...
20 KB (2,238 words) - 11:30, 22 February 2024
Herpes simplex virus (section Gene expression)
early genes. Early gene products help to replicate the viral DNA. Viral DNA replication, in turn, stimulates the expression of the late genes, encoding...
68 KB (7,410 words) - 03:52, 4 December 2024
Homeobox (redirect from Homeobox gene)
structure that binds DNA to regulate expression of target genes. Homeodomain proteins regulate gene expression and cell differentiation during early...
41 KB (4,386 words) - 08:06, 31 December 2024
variants are known to exist, FAP and attenuated FAP (originally called hereditary flat adenoma syndrome) are caused by APC gene defects on chromosome 5 while...
42 KB (3,838 words) - 16:45, 27 January 2024
Operon (redirect from Operator gene)
but sometimes more control over the gene expression is needed. To achieve this aspect, some bacterial genes are located near together, but there is a...
21 KB (2,544 words) - 00:40, 27 April 2024
Glucagon-like peptide-1 (section Gene expression)
proglucagon gene expression is promoted upon fasting and hypoglycaemia induction and inhibited by insulin. Conversely, intestinal proglucagon gene expression is...
29 KB (3,615 words) - 00:55, 30 December 2024
Post-transcriptional regulation (category Gene expression)
process to regulate gene expression. An example of regulated nuclear transport of mRNA can be observed in HIV. Transcription attenuation is a type of prokaryotic...
27 KB (3,383 words) - 01:17, 8 September 2024
Programmed cell death protein 1 (redirect from PDCD1 (gene))
IL-10 production which inhibits CD4 T-cell function. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected...
39 KB (4,995 words) - 22:41, 14 December 2024
Sonic hedgehog protein (redirect from Sonic hedgehog (gene))
heavily on proper expression of the SHH gene and subsequent sonic hedgehog protein, earning it the distinction of being an essential gene to development...
62 KB (7,266 words) - 22:34, 17 January 2025
Pparg coactivator 1 alpha (redirect from PPARGC1A (gene))
regulator of liver gluconeogenesis, inducing increased gene expression for gluconeogenesis. PGC-1α is a gene that contains two promoters, and has 4 alternative...
32 KB (3,869 words) - 14:22, 16 January 2025
Tumor necrosis factor (redirect from TNF (gene))
the synthesis of new proteins, enabling rapid activation of the gene. TNF gene expression is regulated by a proximal promoter region consisting of approximately...
49 KB (6,227 words) - 14:52, 18 November 2024
Alpha-2A adrenergic receptor (redirect from ADRA2A (gene))
Cragoe EJ, Limbird LE (October 1990). "Cloning, sequencing, and expression of the gene encoding the porcine alpha 2-adrenergic receptor. Allosteric modulation...
12 KB (1,303 words) - 04:16, 13 August 2024
Adenosine deaminase (redirect from ADA (gene))
L, et al. (Feb 1985). "Adenosine deaminase: characterization and expression of a gene with a remarkable promoter". The EMBO Journal. 4 (2): 437–43. doi:10...
26 KB (3,060 words) - 22:43, 17 August 2024
Alpha-synuclein (redirect from SNCA (gene))
"Distinct pattern of enteric phospho-alpha-synuclein aggregates and gene expression profiles in patients with Parkinson's disease". Acta Neuropathologica...
83 KB (9,387 words) - 04:46, 6 January 2025
The LBH (Limb Bud-Heart) gene is a highly conserved human gene that produces the LBH protein, a transcription co-factor in the Wnt/β-catenin pathway....
13 KB (1,576 words) - 19:25, 10 December 2023
neurogenesis by activating the expression of a cascade of neuronal genes, but they inhibit the expression of glial genes. Neural bHLH genes have different functions...
48 KB (5,032 words) - 16:08, 10 April 2024
P-glycoprotein (redirect from ABCB1 (gene))
regulation of P-gp; the p38 MAPK pathway negatively regulates the expression of the P-gp gene; and the JNK pathway was reported to be involved in both positive...
33 KB (3,930 words) - 03:43, 25 December 2024
Tenascin C (redirect from TNC (gene))
ligands fibronectin and tenascin collaborate in regulating collagenase gene expression in fibroblasts". Mol. Biol. Cell. 5 (4): 439–53. doi:10.1091/mbc.5...
20 KB (2,565 words) - 04:57, 23 December 2023
Glycogen synthase kinase-3 beta (redirect from GSK3B (gene))
humans is encoded by the GSK3B gene. In mice, the enzyme is encoded by the Gsk3b gene. Abnormal regulation and expression of GSK-3 beta is associated with...
17 KB (1,819 words) - 16:52, 22 May 2024
DDX3X (redirect from DDX3X (gene))
with low MITF expression. Mutations of the DDX3X gene are associated with medulloblastoma. In melanoma, the low expression of the gene is linked to poor...
18 KB (1,859 words) - 03:29, 30 December 2024
gene. This metastasis suppressor gene product is a membrane glycoprotein that is a member of the tetraspanin/transmembrane 4 superfamily. Expression of...
11 KB (1,382 words) - 07:19, 15 October 2024
FOSB (redirect from FOSB (gene))
, an abnormally and excessively high level of ΔFosB expression which produces a pronounced gene-related phenotype) triggers the development of addiction-related...
57 KB (7,191 words) - 15:49, 9 January 2025
MicroRNA (category Gene expression)
are involved in RNA silencing and post-transcriptional regulation of gene expression. miRNAs base-pair to complementary sequences in messenger RNA (mRNA)...
148 KB (16,818 words) - 22:42, 12 November 2024
Fibroblast activation protein, alpha (redirect from FAP (gene))
prolyl endopeptidase FAP is an enzyme that in humans is encoded by the FAP gene. Prolyl endopeptidase FAP is a 170 kDa membrane-bound gelatinase. It was...
17 KB (2,086 words) - 09:37, 10 March 2024