In biochemistry, a ligase is an enzyme that can catalyze the joining (ligation) of two molecules by forming a new chemical bond. This is typically via...
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DNA ligase is a type of enzyme that facilitates the joining of DNA strands together by catalyzing the formation of a phosphodiester bond. It plays a role...
23 KB (2,787 words) - 00:53, 18 June 2024
A ubiquitin ligase (also called an E3 ubiquitin ligase) is a protein that recruits an E2 ubiquitin-conjugating enzyme that has been loaded with ubiquitin...
24 KB (2,755 words) - 04:56, 29 September 2024
ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases (E3s), respectively. The result of this sequential cascade is to bind ubiquitin...
97 KB (11,021 words) - 17:45, 18 September 2024
List of EC numbers (EC 6) (redirect from Carbon-carbon ligases)
tyrosine—tRNA ligase EC 6.1.1.2: tryptophan—tRNA ligase EC 6.1.1.3: threonine—tRNA ligase EC 6.1.1.4: leucine—tRNA ligase EC 6.1.1.5: isoleucine—tRNA ligase EC 6...
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into a single polymeric chain through the action of an enzyme known as a ligase. The reaction involves the formation of a phosphodiester bond between the...
36 KB (4,717 words) - 15:19, 12 September 2024
DNA ligase 1 also DNA ligase I, is an enzyme that in humans is encoded by the LIG1 gene. DNA ligase 1 is the only known eukaryotic DNA ligase involved...
23 KB (2,878 words) - 08:09, 5 August 2024
The RNA Ligase ribozyme was the first of several types of synthetic ribozymes produced by in vitro evolution and selection techniques. They are an important...
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Succinate—CoA ligase (ADP-forming) EC 6.2.1.6: Glutarate—CoA ligase EC 6.2.1.7: Cholate—CoA ligase EC 6.2.1.8: Oxalate—CoA ligase EC 6.2.1.9: Malate—CoA ligase EC...
33 KB (3,650 words) - 18:48, 10 September 2024
deoxyribonucleic ligase, deoxyribonucleic repair enzyme, deoxyribonucleic joinase, DNA ligase, deoxyribonucleate ligase, polynucleotide ligase, deoxyribonucleic...
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Acetyl-CoA synthetase (redirect from Acetate—CoA ligase)
synthetase (ACS) or Acetate—CoA ligase is an enzyme (EC 6.2.1.1) involved in metabolism of acetate. It is in the ligase class of enzymes, meaning that...
17 KB (2,150 words) - 18:36, 11 September 2024
DNA ligase 3 also DNA ligase III, is an enzyme that, in humans, is encoded by the LIG3 gene. LIG3 encodes ATP-dependent DNA ligases that seal interruptions...
30 KB (3,749 words) - 18:26, 16 August 2024
Okazaki fragments (section DNA ligase I)
synthesized discontinuously and later linked together by the enzyme DNA ligase to create the lagging strand during DNA replication. They were discovered...
33 KB (4,435 words) - 14:24, 7 June 2024
Cholate—CoA ligase (EC 6.2.1.7, BAL, bile acid CoA ligase, bile acid coenzyme A ligase, choloyl-CoA synthetase, choloyl coenzyme A synthetase, cholic thiokinase...
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The ligase chain reaction (LCR) is a method of DNA amplification. The ligase chain reaction (LCR) is an amplification process that differs from PCR in...
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Glutamine synthetase (redirect from Glutamate—ammonia ligase)
glutamate—ammonia ligase Active site between two monomers of glutamine synthetase from Salmonella typhimurium. Cation binding sites are yellow and orange;...
29 KB (3,063 words) - 07:32, 22 June 2024
Parkin (protein) (redirect from Parkin (ligase))
Parkin is a 465-amino acid residue E3 ubiquitin ligase, a protein that in humans and mice is encoded by the PARK2 gene. Parkin plays a critical role in...
47 KB (5,731 words) - 11:29, 22 June 2024
RTCB (redirect from RNA 2',3'-cyclic phosphate and 5'-OH ligase)
RNA 2',3'-cyclic phosphate and 5'-OH ligase is a protein that in humans is encoded by the RTCB gene. It is found in the stress granule of cells. As of...
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Glutamate–cysteine ligase (GCL) EC 6.3.2.2), previously known as γ-glutamylcysteine synthetase (GCS), is the first enzyme of the cellular glutathione (GSH)...
19 KB (2,296 words) - 16:36, 22 September 2024
In enzymology, a 4-coumarate—CoA ligase (EC 6.2.1.12) is an enzyme that catalyzes the chemical reaction ATP + 4-coumarate + CoA ⇌ {\displaystyle \rightleftharpoons...
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enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic...
21 KB (2,033 words) - 06:45, 23 September 2024
[glutamate—ammonia-ligase] adenylyltransferase (EC 2.7.7.42) is an enzyme that catalyzes the chemical reaction ATP + [L-glutamate:ammonia ligase (ADP-forming)]...
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layer. Stage two involves four key Mur ligase enzymes: MurC, MurD, MurE (EC) and MurF (EC). These four Mur ligases are responsible for the successive additions...
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UBE3A (redirect from Ubiquitin protein ligase E3A)
Ubiquitin-protein ligase E3A (UBE3A) also known as E6AP ubiquitin-protein ligase (E6AP) is an enzyme that in humans is encoded by the UBE3A gene. This...
13 KB (1,508 words) - 10:38, 21 December 2023
SCF complex (redirect from SCF ubiquitin ligase complex)
F-box containing complex (or SCF complex) is a multi-protein E3 ubiquitin ligase complex that catalyzes the ubiquitination of proteins destined for 26S proteasomal...
16 KB (2,021 words) - 19:31, 28 January 2023
DNA ligase 4 also DNA ligase IV, is an enzyme that in humans is encoded by the LIG4 gene. DNA ligase 4 is an ATP-dependent DNA ligase that joins double-strand...
15 KB (1,821 words) - 05:44, 11 June 2024
2-amino-2-deoxy-alpha-D-glucopyranoside ligase (EC 6.3.1.13, MshC, MshC ligase, Cys:GlcN-Ins ligase, mycothiol ligase) is an enzyme with systematic name...
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succinate-CoA ligase (A-SUCL, EC 6.2.1.5) or a GDP-forming succinate-CoA ligase (G-SUCL, EC 6.2.1.4). The ADP-forming succinate-CoA ligase is potentially...
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5-MeO-aMT (redirect from Xanthosine-5'-phosphate:ammonia ligase)
5-MeO-αMT or 5-methoxy-α-methyltryptamine, α,O-Dimethylserotonin (Alpha-O) is a potent psychedelic tryptamine. It is soluble in ethanol. The sympathomimetic...
14 KB (1,159 words) - 16:00, 14 April 2024
DTX3L (redirect from Deltex e3 ubiquitin ligase 3l)
Deltex E3 ubiquitin ligase 3L is a protein that in humans is encoded by the DTX3L gene. It functions as an ubiquitin ligase (E3), and is over-expressed...
8 KB (1,057 words) - 02:55, 21 July 2024