Micro ribonucleic acid (microRNA, miRNA, µRNA) are small, single-stranded, non-coding RNA molecules containing 21–23 nucleotides. Found in plants, animals...
148 KB (16,818 words) - 04:03, 13 October 2024
MicroRNA sequencing (miRNA-seq), a type of RNA-Seq, is the use of next-generation sequencing or massively parallel high-throughput DNA sequencing to sequence...
49 KB (5,200 words) - 07:39, 12 December 2023
Gary Ruvkun (section microRNA, let-7)
by which lin-4, the first microRNA (miRNA) discovered by Victor Ambros, regulates the translation of target messenger RNAs via imperfect base-pairing...
33 KB (3,190 words) - 19:17, 19 October 2024
ribonucleic acid (RNA) molecules, microRNA (miRNA) and small interfering RNA (siRNA), are central to components to the RNAi pathway. Once mRNA is degraded,...
141 KB (15,474 words) - 15:59, 8 October 2024
RNAs such as microRNAs, siRNAs, piRNAs, snoRNAs, snRNAs, exRNAs, scaRNAs and the long ncRNAs such as Xist and HOTAIR. The number of non-coding RNAs within...
68 KB (7,253 words) - 04:01, 23 June 2024
developmental biologist and Nobel Laureate who discovered the first known microRNA (miRNA). He is a professor at the University of Massachusetts Medical School...
20 KB (1,740 words) - 20:02, 17 October 2024
Gene expression (redirect from RNA expression)
expression of microRNAs. In breast cancer, transcriptional repression of BRCA1 may occur more frequently by over-transcribed microRNA-182 than by hypermethylation...
102 KB (11,438 words) - 16:50, 17 July 2024
Farrell, Jr. RNA Methodologies, 5th Edition. Academic Press, 2017 Brennecke J, Stark A, Russell RB, Cohen SM (March 2005). "Principles of microRNA-target recognition"...
50 KB (6,021 words) - 19:21, 15 October 2024
PMID 19765283. Thadani R, Tammi MT (December 2006). "MicroTar: predicting microRNA targets from RNA duplexes". BMC Bioinformatics. 7. 7 (Suppl 5): S20....
150 KB (8,425 words) - 09:42, 5 October 2024
MicroRNA (miRNA) biosensors are analytical devices that involve interactions between the target miRNA strands and recognition element on a detection platform...
64 KB (7,163 words) - 19:55, 26 June 2024
transfer RNA (tRNA), microRNA (miRNA), small interfering RNA (siRNA), small nucleolar RNA (snoRNAs), Piwi-interacting RNA (piRNA), tRNA-derived small RNA (tsRNA)...
65 KB (7,609 words) - 04:25, 14 October 2024
Glioblastoma (section MicroRNA)
the sinuous extracellular matrix of the brain. As of 2012, RNA interference, usually microRNA, was under investigation in tissue culture, pathology specimens...
78 KB (8,704 words) - 07:39, 8 October 2024
molecular biology in May 2017. He defended his thesis, "Discovery of mature microRNA sequences within the protein-coding regions of global HIV-1 genomes: predictions...
31 KB (2,696 words) - 00:15, 17 October 2024
molecules, typically 20–24 base pairs in length, similar to microRNA (miRNA), and operating within the RNA interference (RNAi) pathway. It interferes with the...
56 KB (6,827 words) - 12:42, 7 October 2024
This microRNA database and microRNA targets databases is a compilation of databases and web portals and servers used for microRNAs and their targets....
23 KB (1,649 words) - 21:57, 19 September 2024
Han J, Yeom KH, Lee S, Baek SH, et al. (October 2004). "MicroRNA genes are transcribed by RNA polymerase II". The EMBO Journal. 23 (20): 4051–4060. doi:10...
43 KB (5,103 words) - 08:16, 9 September 2024
biomedical scientist, best known for her breakthrough paper on the discovery of microRNA which was published in 1993. In 2002, Lee was joint receipient of the Newcomb...
8 KB (630 words) - 01:29, 20 October 2024
larger class of non-coding RNAs termed microRNAs. miR-98 microRNA precursor from human is a let-7 family member. Let-7 miRNAs have now been predicted or...
70 KB (8,221 words) - 23:58, 1 September 2024
example is RNA interference (RNAi), in which endogenously expressed microRNA (miRNA) or exogenously derived small interfering RNA (siRNA) induces the...
47 KB (5,449 words) - 00:50, 6 August 2024
Regulus Therapeutics (section microRNA explained)
expression. Anti-miR therapeutics inhibit specific microRNA targets. Animal models showed that modulating microRNAs through anti-miRs effectively regulates biological...
5 KB (342 words) - 18:59, 4 July 2024
levels. Using single-stranded RNA (ssRNA) fragments, such as microRNA (miRNA), or double-stranded small interfering RNA (siRNA), the complex functions as...
36 KB (3,836 words) - 14:30, 19 April 2024
Dicer (category MicroRNA)
double-stranded RNA (dsRNA) and pre-microRNA (pre-miRNA) into short double-stranded RNA fragments called small interfering RNA and microRNA, respectively...
26 KB (3,267 words) - 20:14, 27 September 2024
In molecular biology lin-4 is a microRNA (miRNA) that was identified from a study of developmental timing in the nematode Caenorhabditis elegans. It was...
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body-specific RNA, by Dicer. This small RNA was found to function as a microRNA. Potential microRNAs were also identified in several other Human snoRNAs. Giardia...
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encoding microRNA MicroRNA 106 MIR222: encoding microRNA MicroRNA 222 MIR223: encoding protein MicroRNA 223 MIR361: encoding microRNA MicroRNA 361 MIR503:...
42 KB (3,912 words) - 12:31, 21 October 2024
Cancer epigenetics (section MicroRNA gene silencing)
et al. (February 2013). "MicroRNA-182-5p targets a network of genes involved in DNA repair". RNA. 19 (2): 230–242. doi:10.1261/rna.034926.112. PMC 3543090...
111 KB (12,533 words) - 04:42, 11 August 2024
Regulation of gene expression (category RNA)
the gene. RNA can be an important regulator of gene activity, e.g. by microRNA (miRNA), antisense-RNA, or long non-coding RNA (lncRNA). LncRNAs differ from...
45 KB (5,236 words) - 14:22, 7 October 2024
Short interspersed nuclear element (section microRNAs)
generate novel microRNA loci was analyzed. It was found that genes which were predicted to possess V-SINEs were targeted by microRNAs with significantly...
41 KB (5,252 words) - 08:25, 18 July 2024
into precursors of messenger RNA (mRNA) and most small nuclear RNA (snRNA) and microRNA. It is one of the three RNAP enzymes found in the nucleus of eukaryotic...
27 KB (3,100 words) - 17:09, 21 April 2024
ncRNAs from small non-coding RNAs, such as microRNAs (miRNAs), small interfering RNAs (siRNAs), Piwi-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs)...
115 KB (12,353 words) - 17:28, 3 October 2024