nucleophilic substitution, whereby a nucleophile becomes attracted to a full or partial positive charge, and nucleophilic addition. Nucleophilicity is...

In chemistry, a nucleophilic substitution (SN) is a class of chemical reactions in which an electron-rich chemical species (known as a nucleophile) replaces...

Aromatic rings are usually nucleophilic, but some aromatic compounds do undergo nucleophilic substitution. Just as normally nucleophilic alkenes can be made...

The bimolecular nucleophilic substitution (SN2) is a type of reaction mechanism that is common in organic chemistry. In the SN2 reaction, a strong nucleophile...

In organic chemistry, a nucleophilic addition (AN) reaction is an addition reaction where a chemical compound with an electrophilic double or triple bond...

The unimolecular nucleophilic substitution (SN1) reaction is a substitution reaction in organic chemistry. The Hughes-Ingold symbol of the mechanism expresses...

reactions in organic chemistry are classified either as electrophilic or nucleophilic depending upon the reagent involved, whether a reactive intermediate...

Nucleophilic conjugate addition is a type of organic reaction. Ordinary nucleophilic additions or 1,2-nucleophilic additions deal mostly with additions...

As the name suggests, a non-nucleophilic base is a sterically hindered organic base that is a poor nucleophile. Normal bases are also nucleophiles, but...

β-lactamases). An acid-base-nucleophile triad is a common motif for generating a nucleophilic residue for covalent catalysis. The residues form a charge-relay network...

In organic chemistry, the vicarious nucleophilic substitution is a special type of nucleophilic aromatic substitution in which a nucleophile replaces...

Radical-nucleophilic aromatic substitution or SRN1 in organic chemistry is a type of substitution reaction in which a certain substituent on an aromatic...

esters, and amides. Carboxylate ions are essentially unreactive towards nucleophilic substitution, since they possess no leaving group. The reactivity of...

Nucleophilic abstraction is a type of an organometallic reaction which can be defined as a nucleophilic attack on a ligand which causes part or all of...

S2CID 4326584. Bender ML (1 January 1962). "Metal Ion Catalysis of Nucleophilic Organic Reactions in Solution". Reactions of Coordinated Ligands. Advances...

due to high C:H ratio Undergo electrophilic substitution reactions and nucleophilic aromatic substitutions Arenes are typically split into two categories...

(substitution nucleophilic internal) refers to a specific, regio-selective but not often encountered reaction mechanism for nucleophilic aliphatic substitution...

Nucleophilic epoxidation is the formation of epoxides from electron-deficient double bonds through the action of nucleophilic oxidants. Nucleophilic epoxidation...

dealkylation. Alkylating agents are often classified according to their nucleophilic or electrophilic character. In oil refining contexts, alkylation refers...

electronegativity of the oxygen is greater than that for carbon. Thus, ketones are nucleophilic at oxygen and electrophilic at carbon. Because the carbonyl group interacts...

chemist Siegfried Hünig [de]. It is used in organic chemistry as a non-nucleophilic base. It is commonly abbreviated as DIPEA, DIEA, or i-Pr2NEt. DIPEA consists...

complex molecules. Nucleophilic/electrophilic cascades are defined as the cascade sequences in which the key step constitutes a nucleophilic or electrophilic...

enzymes that cleave peptide bonds in proteins. Serine serves as the nucleophilic amino acid at the (enzyme's) active site. They are found ubiquitously...

intramolecular nucleophilic substitution of a halohydrin. Many ethers, ethoxylates and crown ethers, are produced from epoxides. Nucleophilic displacement...

with glycosidic bond formation at the same time in a one-pot procedure. Nucleophilic displacement can be an effective strategy for the synthesis of amino...

used in organic synthesis as a catalyst, a complexing ligand, and a non-nucleophilic base. Although all commercially available DBU is produced synthetically...

reactive. Their reactivity can be classified in three main classes: (1) nucleophilic additions, (2) pericyclic reactions, and (3) bond-insertion. Upon treatment...

Primary alkyl halides react with aqueous NaOH or KOH to give alcohols in nucleophilic aliphatic substitution. Secondary and especially tertiary alkyl halides...

electron density and enter nucleophilic aromatic substitution only with very strong electron withdrawing groups. Nucleophilic substitution can take place...

In organic chemistry, vinylation is the process of attaching a vinyl group (CH2=CH−) to a substrate. Many organic compounds contain vinyl groups, so the...