5α-Reductases, also known as 3-oxo-5α-steroid 4-dehydrogenases, are enzymes involved in steroid metabolism. They participate in three metabolic pathways:...

5α-Reductase 2 deficiency (5αR2D) is an autosomal recessive condition caused by a mutation in SRD5A2, a gene encoding the enzyme 5α-reductase type 2 (5αR2)...

agents inhibit the enzyme 5α-reductase, which is involved in the metabolic transformations of a variety of endogenous steroids. 5-ARIs are most known for...

Dihydrotestosterone (DHT, 5α-dihydrotestosterone, 5α-DHT, androstanolone or stanolone) is an endogenous androgen sex steroid and hormone primarily involved...

This is a list of 5α-reductase inhibitors (5α-RIs), drugs which inhibit one or more isoforms of the enzyme 5α-reductase. This enzyme is responsible for...

3-Oxo-5α-steroid 4-dehydrogenase 1 is an enzyme that in humans is encoded by the SRD5A1 gene. It is one of three forms of steroid 5α-reductase. Steroid 5α-reductase...

conversion via 5α-reductase into DHT in tissues where 5α-reductase is expressed, an AAS that is not metabolized by 5α-reductase or is already 5α-reduced, such...

encodes the 3-oxo-5α-steroid 4-dehydrogenase 2 enzyme, also known as 5α-reductase type 2 (5αR2), one of three isozymes of 5α-reductase. 5αR2 catalyzes the...

5α-estran-17β-ol-3-one) is a naturally occurring anabolic–androgenic steroid (AAS) and a 5α-reduced derivative of nandrolone (19-nortestosterone). It is a major...

exposure by acting specifically on hair follicles. Finasteride is a 5α-reductase inhibitor and therefore an antiandrogen. It works by decreasing the production...

Russell, David W.; Wilson, Jean D. (October 2016). "Steroid 5α-reductase 2 deficiency". The Journal of Steroid Biochemistry and Molecular Biology. 163: 206–211...

development of 5α-reductase inhibitors (5-ARIs), also known as dihydrotestosterone (DHT) blockers. These are two types of 5-ARIs, categorized as steroidal and nonsteroidal...

member of the cytochrome P450 family of enzymes), 5α-Reductase and 3α-Hydroxysteroid dehydrogenase. Steroids are primarily oxidized by cytochrome P450 oxidase...

Steroid reductases are reductase enzymes that are involved in steroid biosynthesis and metabolism. They include: 5α-Reductase 5β-Reductase Steroidogenic...

This process starts with 21-carbon (C 21) steroids, also known as pregnanes, and involves a step called "5α-reduction". Notably, this pathway does not...

hypotheses have been advanced. These include the non-activation of SARMs by 5α-reductase, tissue selective expression of androgen receptor coregulators, non-genomic...

allopregnanolone and isopregnanolone from progesterone. 5α-DHP is metabolized by the aldo-keto reductases (AKRs) AKR1C1, AKR1C2, and AKR1C4 with high catalytic...

as 5α-estran-3α-ol-17-one, is a metabolite of nandrolone (19-nortestosterone) and bolandione (19-norandrostenedione) that is formed by 5α-reductase. It...

Androstanedione, also known as 5α-androstanedione or as 5α-androstane-3,17-dione, is a naturally occurring androstane (5α-androstane) steroid and an endogenous metabolite...

ingentaconnect.com/content/ben/cpd/2011/00000017/00000002/art00008 "Steroid 5α-reductase as a novel therapeutic target for schizophrenia and other neuropsychiatric...

the enzyme 5α-reductase from the adrenal hormone DHEA.[verification needed] Epiandrosterone can also be produced from the natural steroids androstanediol...

norethisterone, its major active metabolite 5α-dihydronorethisterone (5α-DHNET), which is formed by transformation via 5α-reductase, has been found to possess both...

Androsterone, or 3α-hydroxy-5α-androstan-17-one, is an endogenous steroid hormone, neurosteroid, and putative pheromone. It is a weak androgen with a...

masculinization. Besides the involvement of 5α-reductase in androgen signaling, it is also required for the conversion of steroid hormones such as progesterone and...

studies showing that it is metabolized by aromatase or 5α-reductase into estrogenic compounds, or into 5α-reduced androgenic compounds, respectively. The potency...

activity. 5α-DHNET is formed from norethisterone by 5α-reductase in the liver and other tissues. Unlike norethisterone which is purely progestogenic, 5α-DHNET...

Androstenol, also known as 5α-androst-16-en-3α-ol (shortened to 3α,5α-androstenol or 3α-androstenol), is a 16-androstene class steroidal pheromone and neurosteroid...

catalyzed by 5α-reductase in tissues that express the enzyme in high amounts like the liver, skin, hair follicles, and prostate gland. 5α-DHET has significant...

dehydrogenase (3β-HSD), 17β-hydroxysteroid dehydrogenase (17β-HSD), 5α-reductase, and steroid sulfatase (STS), necessary to transform adrenal androgens like...

of enlarged prostate in China. It is taken by mouth. Epristeride is a 5α-reductase inhibitor and works by decreasing the production of dihydrotestosterone...