Irinotecan, sold under the brand name Camptosar among others, is an anti-cancer medication used to treat colon cancer and small cell lung cancer. For colon...
26 KB (2,315 words) - 04:55, 13 April 2024
which incorporates into the DNA molecule and stops synthesis; and IRI – irinotecan (Camptosar), a topoisomerase inhibitor, which prevents DNA from uncoiling...
4 KB (411 words) - 21:05, 6 May 2024
active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor) but has 1000 times more activity than irinotecan itself. In vitro...
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Atropine (section Irinotecan induced diarrhea)
Europe during the Cold War. Atropine has been observed to prevent or treat irinotecan induced acute diarrhea. Adverse reactions to atropine include ventricular...
39 KB (3,656 words) - 02:05, 17 September 2024
compare the efficacy of Abituzumab, cetuximab, and irinotecan compared to cetuximab and irinotecan in patients with KRAS (exon 2) wild-type metastatic...
9 KB (974 words) - 19:52, 20 December 2023
]] [[ ]] [[ ]] [[ ]] |alt=Irinotecan Pathway edit]] The interactive pathway map can be edited at WikiPathways: "IrinotecanPathway_WP229". Glucuronosyltransferase...
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antineoplastic agent, which inhibits DNA repair and/or DNA synthesis; IRI – irinotecan (Camptosar), a topoisomerase inhibitor, prevents DNA from uncoiling and...
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effectiveness to prevent diarrhea in cancer patients who have received irinotecan. It can interfere with the absorption of some medications, and lead to...
15 KB (1,215 words) - 20:28, 12 August 2024
Romidepsin Vorinostat Zabadinostat Belotecan Camptothecin Exatecan Gimatecan Irinotecan Topotecan Etoposide Teniposide Tafluposide Bortezomib Erlotinib Gefitinib...
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colorectal cancer who received prior fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy, an anti-VEGF therapy, and, if RAS wild-type and medically...
10 KB (579 words) - 06:46, 26 June 2024
Aflibercept (Zaltrap), in combination with fluorouracil, leucovorin, and irinotecan (known as FOLFIRI), is indicated for the treatment of people with metastatic...
34 KB (2,404 words) - 18:19, 5 October 2024
inhibitors. One of the first inhibitors shown to target TOP1 is irinotecan. Irinotecan is an analogue of the cytotoxic natural alkaloid camptothecin, obtained...
16 KB (2,141 words) - 02:28, 29 November 2023
with severe diarrhea and neutropenia in patients who are treated with irinotecan, which is metabolized by UGT1A1. While paracetamol (acetaminophen) is...
36 KB (3,719 words) - 12:42, 16 July 2024
which incorporates into the DNA molecule and stops DNA synthesis; IRIN – irinotecan (Camptosar), a topoisomerase inhibitor, which prevents DNA from uncoiling...
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under investigation for or used as drugs for cancer treatment, including irinotecan, topotecan, rubitecan. C. acuminata also contains the chemical compounds...
2 KB (192 words) - 22:31, 28 April 2024
include a combination of chemotherapy (paclitaxel and carboplatin or irinotecan plus cisplatin) and surgical resection in ovarian clear-cell carcinoma;...
3 KB (333 words) - 01:07, 3 December 2023
generic versions of intravenous oncology products such as Paclitaxel, Irinotecan, Oxaliplatin, Gemcitabine, Cytarabine, Carboplatin, Topotecan, Docetaxel...
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the disease. In February 2024, Ipsen received FDA approval for Onivyde (irinotecan liposome injection), which is used in combination with oxaliplatin, fluorouracil...
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nucleotides Daunorubicin, Doxorubicin, Epirubicin Enzyme inhibitors inhibit enzymes that are crucial to DNA replication Decitabine, Etoposide, Irinotecan...
29 KB (3,522 words) - 12:25, 12 July 2024
for a small number of drugs that are very toxic to the intestine (e.g. irinotecan), these molecules which would not otherwise be very toxic can become so...
6 KB (770 words) - 10:04, 13 September 2024
ways: Rotor syndrome may exacerbate toxic side effects of the medication irinotecan. Rotor syndrome is caused by mutations in two proteins responsible for...
10 KB (1,045 words) - 05:16, 13 August 2024
(Belotecan Camptothecin Cositecan† Etirinotecan pegol† Exatecan Gimatecan Irinotecan# Lurtotecan‡ Rubitecan‡ Silatecan§ Topotecan) II Podophyllum (Etoposide#...
31 KB (2,908 words) - 06:38, 22 September 2024
topotecan (TPT), irinotecan, and belotecan. TPT is commonly used to treat ovarian and small cell lung cancer (SCLC) while irinotecan is known to improve...
85 KB (9,593 words) - 19:07, 8 September 2024
(Belotecan Camptothecin Cositecan† Etirinotecan pegol† Exatecan Gimatecan Irinotecan# Lurtotecan‡ Rubitecan‡ Silatecan§ Topotecan) II Podophyllum (Etoposide#...
36 KB (3,278 words) - 07:36, 30 September 2024
chemotherapeutic – cisplatin or carboplatin – combined with either etoposide or irinotecan. This is typically combined with thoracic radiation therapy – 45 Gray...
90 KB (9,784 words) - 07:53, 10 October 2024
inhibitors that inhibit the enzyme. Type 1 topoisomerase is inhibited by irinotecan, topotecan, hexylresorcinol and camptothecin. The human topoisomerase...
19 KB (2,345 words) - 07:02, 26 August 2024
chemotherapy is given the FOLFIRINOX regimen containing fluorouracil, irinotecan, oxaliplatin and leucovorin has been shown to extend survival beyond traditional...
51 KB (5,703 words) - 15:53, 11 October 2024
4 mg/kg intravenously every three weeks or physician's choice of either irinotecan or paclitaxel monotherapy. Efficacy was based on DESTINY-Breast03 (NCT03529110)...
25 KB (2,086 words) - 02:24, 16 July 2024
such as irinotecan. This effect is derived from the microbiome-encoded β-glucuronidase enzymes which recover the active form of the irinotecan causing...
129 KB (14,351 words) - 14:57, 7 October 2024
(2004). "A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic...
10 KB (1,337 words) - 04:46, 21 April 2023