a nucleophilic substitution (SN) is a class of chemical reactions in which an electron-rich chemical species (known as a nucleophile) replaces a functional...

A substitution reaction (also known as single displacement reaction or single substitution reaction) is a chemical reaction during which one functional...

nucleophilic substitution (SN2) is a type of reaction mechanism that is common in organic chemistry. In the SN2 reaction, a strong nucleophile forms a new...

A nucleophilic aromatic substitution (SNAr) is a substitution reaction in organic chemistry in which the nucleophile displaces a good leaving group, such...

alcohols and water are named solvolysis. Nucleophiles may take part in nucleophilic substitution, whereby a nucleophile becomes attracted to a full or partial...

Some aliphatic compounds can undergo electrophilic substitution as well. In electrophilic substitution in aromatic compounds, an atom appended to the aromatic...

The unimolecular nucleophilic substitution (SN1) reaction is a substitution reaction in organic chemistry. The Hughes-Ingold symbol of the mechanism expresses...

towards nucleophiles, followed by anhydrides, esters, and amides. Carboxylate ions are essentially unreactive towards nucleophilic substitution, since...

coordination sphere of the metal undergoing substitution. The concentration of the substituting nucleophile has no influence on this rate, and an intermediate...

Trost allylic alkylation or allylic alkylation) is a palladium-catalysed substitution reaction involving a substrate that contains a leaving group in an allylic...

Radical-nucleophilic aromatic substitution or SRN1 in organic chemistry is a type of substitution reaction in which a certain substituent on an aromatic...

alternative to aromatic substitution is electrophilic aliphatic substitution. It is similar to the nucleophilic aliphatic substitution and also has two major...

substitution with an organozinc nucleophile and peptide ligand. A TaniaPHOS ligand, a ferrocenylphosphine, is used with a methyl Grignard nucleophile...

the vicarious nucleophilic substitution is a special type of nucleophilic aromatic substitution in which a nucleophile replaces a hydrogen atom on the...

A carbonyl α-substitution reaction occurs at the position next to the carbonyl group, the α-position, and involves the substitution of an α-hydrogen by...

deficient (electrophilic) carbon which, inevitably, attracts nucleophiles. Substitution reactions involve the replacement of the halogen with another...

activated complex. The solvent used in substitution reactions inherently determines the nucleophilicity of the nucleophile; this fact has become increasingly...

chemistry, solvolysis is a type of nucleophilic substitution (SN1/SN2) or elimination where the nucleophile is a solvent molecule. Characteristic of SN1...

aromatic substitution, when the active reagent is an electrophile, and nucleophilic aromatic substitution, when the reagent is a nucleophile. In radical-nucleophilic...

hydrolysis, the Cannizzaro reaction, nucleophilic aliphatic substitution, nucleophilic aromatic substitution, and in elimination reactions. The reaction medium...

and substitution products form by competing SN1 and E1 pathways. The case of 2° haloalkanes is relatively complex. For strongly basic nucleophiles (pKaH...

are now commonly used in organic synthesis as mild, selective nucleophiles for substitution and conjugate addition reactions. Since the discovery that copper(I)...

organic chemistry describes a special type of substitution reaction. ANRORC stands for Addition of the Nucleophile, Ring Opening, and Ring Closure in nucleophilic...

withdrawing groups and a nucleophile. These complexes are found as reactive intermediates in nucleophilic aromatic substitution but stable and isolated...

same stability. In addition, 2-chlorobutane can be synthesized in a substitution reaction by reacting 2-butanol with hydrochloric acid. In this case,...

In chemistry, SNi (substitution nucleophilic internal) refers to a specific, regio-selective but not often encountered reaction mechanism for nucleophilic...

attacking nucleophile to give a discrete, detectable intermediate followed by loss of another ligand. Complexes that undergo associative substitution are either...

Electrophilic substitution of unsaturated silanes involves attack of an electrophile on an allyl- or vinylsilane. An allyl or vinyl group is incorporated...

Yamashita's dialkyl aluminyl anion can also act as a nucleophile in nucleophilic substitution reactions with electrophiles such as methyl triflate or...

NBS is a chemical reagent used in radical substitution, electrophilic addition, and electrophilic substitution reactions in organic chemistry. NBS can be...