A telomere (/ˈtɛləmɪər, ˈtiːlə-/; from Ancient Greek τέλος (télos) 'end' and μέρος (méros) 'part') is a region of repetitive nucleotide sequences associated...
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The relationship between telomeres and longevity and changing the length of telomeres is one of the new fields of research on increasing human lifespan...
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A telomere is a region of repetitive nucleotide sequences at each end of a chromosome. Telomere may also refer to: Telomere (insect morphology), a type...
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Telomeres, the caps on the ends of eukaryotic chromosomes, play critical roles in cellular aging and cancer. An important facet to how telomeres function...
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Telomerase (category Telomere-related proteins)
ribonucleoprotein that adds a species-dependent telomere repeat sequence to the 3' end of telomeres. A telomere is a region of repetitive sequences at each...
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Hayflick limit (section Telomere length)
expression of an enzyme called telomerase. This enzyme extends telomeres, preventing the telomeres of cancer cells from shortening and giving them infinite...
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Lengthening of Telomeres (also known as "ALT") is a telomerase-independent mechanism by which cancer cells avoid the degradation of telomeres. At each end...
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DNA end resection (section Resection of telomere DSBs)
complex specialized DNA protective packages called telomeres that prevent DNA repair activities. Telomeres and mitotic DSBs have different functionality,...
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1984, Blackburn co-discovered telomerase, the enzyme that replenishes the telomere, with Carol W. Greider. For this work, she was awarded the 2009 Nobel Prize...
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A mega-telomere (also known as an ultra-long telomere or a class III telomere), is an extremely long telomere sequence that sits on the end of chromosomes...
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California, Berkeley. Greider pioneered research on the structure of telomeres, the ends of the chromosomes. She was awarded the 2009 Nobel Prize for...
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A telomere (pl.; telomeres or telomeron), literally "end piece", is a term in insect morphology, and refers to a type of "genital clasper"; i.e.: in Mallophaga...
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Ala-Glu-Asp-Gly and the molecular formula C14H22N4O9. Epitalon appears to induce telomere elongation via increased telomerase activity in human somatic cells in...
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Eternal youth (section Telomeres)
of telomeres is now clearly evident: lengthen the telomeres, lengthen the life. However, a study of the comparative biology of mammalian telomeres indicated...
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multisystem X-linked recessive disorder characterized by excessively short telomeres and is considered a severe form of dyskeratosis congenita. Being an X-linked...
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Telomere resolvase, also known as protelomerase, is an enzyme found in bacteria which contain linear plasmids. In order to prevent exonuclease degradation...
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Cellular senescence (section Role of telomeres)
senescence can be triggered by a DNA damage response due to the shortening of telomeres. Cells can also be induced to senesce by DNA damage in response to elevated...
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MRN complex (section Telomere maintenance)
G-overhang at human telomere ends, which could inhibit the proper formation of the so-called T-loop, destabilizing the telomere as a whole. Telomere lengthening...
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structure. In addition to these stacked structures, telomeres also form large loop structures called telomere loops, or T-loops. Here, the single-stranded DNA...
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Telomeric repeat–containing RNA (category Telomere-related genes)
repeat–containing RNA (TERRA) is a long non-coding RNA transcribed from telomeres - repetitive nucleotide regions found on the ends of chromosomes that...
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Telomere-binding proteins (also known as TERF, TRBF, TRF) function to bind telomeric DNA in various species. In particular, telomere-binding protein refers...
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Telomerase reverse transcriptase (category Telomere-binding proteins)
distinct subgroup of RNA-dependent polymerases. Telomerase lengthens telomeres in DNA strands, thereby allowing senescent cells that would otherwise...
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Hallmarks of aging (section Telomere shortening)
below: Primary hallmarks (causes of damage) Genome instability Telomere shortening (or telomere attrition) Epigenetic alterations Loss of proteostasis macroautophagy...
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playing structural and replicatory roles, such as scaffolding regions, telomeres, centromeres, and origins of replication, plus large numbers of transposable...
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Medicine and the Director of the Telomere Center at Johns Hopkins University. Her research focuses on the role of telomeres in disease. Armanios graduated...
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Collagen loss (section Telomere shortening)
rich repeats. Without telomeres, chromosomes will combine and cause instability in the genes. The enzyme that increases telomere length to prevent them...
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but these components do not always occur. DKC is characterized by short telomeres. The disease initially can affect the skin, but a major consequence is...
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chromosomes. Named regions include: Arms (p and q) Centromere Kinetochore Telomere Sub telomere satellite chromosome or trabant. NOR region During cell division...
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point at which cells can no longer divide due to DNA damage or shortened telomeres. Prior to Leonard Hayflick's theory, Alexis Carrel hypothesized that all...
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