Retinoblastoma (Rb) is a rare form of cancer that rapidly develops from the immature cells of a retina, the light-detecting tissue of the eye. It is the...
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The retinoblastoma protein (protein name abbreviated Rb or pRb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional...
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Trilateral retinoblastoma is a malignant midline primitive neuroectodermal tumor occurring in patients with inherited uni- or bilateral retinoblastoma. In most...
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Retinoblastoma-like 1 (p107), also known as RBL1, is a protein that in humans is encoded by the RBL1 gene. The protein encoded by this gene is similar...
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the retinoblastoma tumor suppressor protein. Alfred Knudson, a pediatrician and cancer geneticist, proposed that in order to develop retinoblastoma, two...
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Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene. Retinoblastoma-like protein 2 has been shown to interact with:...
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Flexner–Wintersteiner rosettes (spoke-and-wheel shaped cell formation seen mainly in retinoblastoma) have been described as a form of palisading. A Flexner–Wintersteiner...
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represented Spain at the 2020 Summer Paralympics. Folgado had bilateral retinoblastoma at two years old, her left eye is totally blind and she has very limited...
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Blastoma (section Retinoblastoma)
often called blasts. Examples are nephroblastoma, medulloblastoma, and retinoblastoma. The suffix -blastoma is used to imply a tumor of primitive, incompletely...
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cases of retinoblastoma, a tumor of the retina that occurs both as an inherited disease and sporadically. He noted that inherited retinoblastoma occurs...
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lentis (PFV/PHPV), retinoblastoma, and retrolental fibroplasia. Because of the potentially life-threatening nature of retinoblastoma, a cancer, that condition...
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cancer. During this transition, G1 cyclin D-Cdk4/6 dimer phosphorylates retinoblastoma releasing transcription factor E2F, which then drives the transition...
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concrete structures Retinoblastoma, a childhood cancer of the eyes caused by a mutation in the retinoblastoma protein Retinoblastoma protein, a tumor suppressor...
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Loss of heterozygosity (section Retinoblastoma)
cancer types where a copy of TP53 gene gets inactivated, 13q14 loss in retinoblastoma with RB1 gene deletion or 11p13 in Wilms' tumor where WT1 gene is lost...
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Gallie CM OOnt is a Canadian ophthalmologist. She is the Head of the Retinoblastoma Program in the Hospital for Sick Children (Toronto) Department of Ophthalmology...
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be benign like dermoid cysts, or malignant like rhabdomyosarcoma and retinoblastoma. The most common eyelid tumor is called basal cell carcinoma. This tumor...
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consists of three proteins: RB – Retinoblastoma protein p107 – Retinoblastoma-like protein 1 p130 – Retinoblastoma-like protein 2 They play crucial roles...
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complex. Cyclin D-CDK4/6 complexes in turn mono-phosphorylates the retinoblastoma susceptibility protein (Rb) to pRb. The un-phosphorylated Rb tumour...
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some of the pathology the red reflex is used to detect. For example, retinoblastoma, a neuroblastic tumor that can cause a dampened or even white reflex...
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Albert's research has focused on ocular tumors, particularly melanoma and retinoblastoma. Albert has published over 600 journal articles and he is the author...
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or bilateral retinoblastoma. When retinoblastoma patients present with pineoblastoma this is characterized as "trilateral retinoblastoma". Up to 5% of...
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Cyclin E/Cdk2 (section Retinoblastoma protein)
at cyclin E's C-terminal region and interacts with proteins of the retinoblastoma family including Rb1, p107, and p130. Cyclin E is predominantly found...
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California. He has Rusyn ancestry. At the age of two he lost his left eye to retinoblastoma and has had a prosthetic eye ever since. As a teenager, he attended...
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firefighter. When he was almost one year old, Healey lost his sight due to retinoblastoma, a rare cancer of the eyes. His eyes had to be surgically removed, and...
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up in Wythenshawe, Manchester. Like her brother Patrick, Aherne had retinoblastoma in childhood, which left her partially sighted in one eye. She attended...
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risk of various cancers also increase the risk of lung cancer, namely retinoblastoma and Li–Fraumeni syndrome. As with all cancers, lung cancer is triggered...
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may play a role in mammalian hair cell regeneration. By modulating retinoblastoma protein activity in rat cochlea, sonic hedgehog allows mature hair cells...
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conditions can transform cells using their early gene products. E1A (binds Retinoblastoma tumor suppressor protein) has been found to immortalize primary cells...
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cyclin-cdk complexes. These cyclin-cdk complexes phosphorylate the Retinoblastoma (Rb) protein, a tumor suppressor bound with the E2F family of transcription...
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by proteins produced by the cell; these inhibitory proteins target retinoblastoma tumor-suppressing proteins. These tumor-suppressing proteins regulate...
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