Sphingosine kinase (SphK) is a conserved lipid kinase that catalyzes formation sphingosine-1-phosphate (S1P) from the precursor sphingolipid sphingosine...
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important phospholipid. Sphingosine can be phosphorylated in vivo via two kinases, sphingosine kinase type 1 and sphingosine kinase type 2. This leads to...
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coordinated for this purpose. Sphingosine kinase (SK) is a lipid kinase that catalyzes the conversion of sphingosine to sphingosine-1-phosphate (S1P). Sphingolipids...
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plasma membrane, will convert ceramide to sphingosine. Sphingosine is then phosphorylated by sphingosine kinase (SK) isoenzymes. There are two identified...
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Sphingosine kinase 1 is an enzyme that in humans is encoded by the SPHK1 gene. Sphingosine kinase 1 phosphorylates sphingosine to sphingosine-1-phosphate...
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SPHK2 (redirect from Sphingosine kinase 2)
Sphingosine kinase 2 is a protein that in humans is encoded by the SPHK2 gene. This gene encodes one of two sphingosine kinase isozymes that catalyze the...
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Lipid signaling (section Sphingosine)
the formation of sphingosine, Moreover, a phosphate group can be attached to ceramide (phosphorylation) by the enzyme, ceramide kinase. It is also possible...
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and becomes active when being phosphorylated by kinases. Then the phosphorylated drug binds to sphingosine receptors: not only S1P1, but also S1P3, S1P4...
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structural analogue of sphingosine and is phosphorylated by sphingosine kinases in the cell (most importantly sphingosine kinase 2). The molecular biology...
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sphingoid bases, which are a set of aliphatic amino alcohols that includes sphingosine. They were discovered in brain extracts in the 1870s and were named after...
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Ceramides are a family of waxy lipid molecules. A ceramide is composed of sphingosine and a fatty acid joined by an amide bond. Ceramides are found in high...
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that is used for the treatment of ulcerative colitis. It is a selective sphingosine-1-phosphate (S1P) receptor modulator that modifies the activity of the...
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The sphingosine-1-phosphate receptors are a class of G protein-coupled receptors that are targets of the lipid signalling molecule Sphingosine-1-phosphate...
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acids from ceramide, producing sphingosine (SPH) which in turn is phosphorylated by a sphingosine kinase to form sphingosine-1-phosphate (S1P). Ceramide...
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Find-me signals (section Sphingosine 1-phosphate (S1P))
recruitment of phagocytes to apoptotic cells is not yet known. Sphingosine kinase 1 and sphingosine kinase 2 have been linked to S1P generation during apoptosis...
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muscle contraction. When transmural pressure increases, sphingosine kinase 1 phosphorylates sphingosine to S1P, which binds to the S1P2 receptor in plasma...
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lipid, recruiting cytosolic proteins to appropriate membranes (e.g., sphingosine kinase 1). PA plays very important role in phototransduction in Drosophila...
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Siponimod, sold under the brand name Mayzent, is a selective sphingosine-1-phosphate receptor modulator for oral use that is used for multiple sclerosis...
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EA, Gomez S, Jaspers I, Allbritton NL (April 2015). "Analysis of sphingosine kinase activity in single natural killer cells from peripheral blood". Integrative...
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have dinner with a group of her scientist friends who speculate that sphingosine kinase could lead to a cure for cancer. As a result, the President demands...
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Opaganib (ABC294640) is a drug which acts as an inhibitor of the enzyme sphingosine kinase 2. It is under development as a potential treatment agent for several...
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inducing PAR-1 dependent sphingosine kinase-1 activation and up-regulating sphingosine-1-phosphate with sphingosine kinase.: 3165 Several studies have...
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N,N-Dimethylsphingosine (also known as DMS) is an inhibitor of sphingosine kinase. In rats with neuropathic pain, the natural metabolite DMS is unregulated...
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SPTTooltip Serine C-palmitoyltransferase Myriocin Ceramidase Ceranib 1 OEA SphKTooltip Sphingosine kinase N,N-DMS Safingol SKI II...
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the synthesis of phosphatidic acids. Autotaxin GPR35 Phosphatidic acid Sphingosine-1-phosphate Gintonin van Corven, Emile J.; Groenink, Alida; Jalink, Kees;...
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shown to involve activation of the enzyme sphingosine kinase, and generation of the bioactive lipid, sphingosine-1-phosphate, which promotes growth by transactivating...
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"Conjugated bile acid-activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression". Hepatology. 61 (4): 1216–26. doi:10...
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SPTTooltip Serine C-palmitoyltransferase Myriocin Ceramidase Ceranib 1 OEA SphKTooltip Sphingosine kinase N,N-DMS Safingol SKI II...
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spacesuit sK1 (program), a fork of the Skencil vector graphics editor Sphingosine kinase 1, a protein SK1 (film), a 2014 French film VR Class Sk1, a locomotive...
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S1PR1 (redirect from Sphingosine-1-phosphate receptor 1)
Sphingosine-1-phosphate receptor 1 (S1P receptor 1 or S1PR1), also known as endothelial differentiation gene 1 (EDG1) is a protein that in humans is encoded...
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