2,6-dihydroxypseudooxynicotine hydrolase
2,6-dihydroxypseudooxynicotine hydrolase | |||||||||
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Identifiers | |||||||||
EC no. | 3.7.1.19 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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2,6-dihydroxypseudooxynicotine hydrolase (EC 3.7.1.19) is an enzyme with systematic name 1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one hydrolase.[1][2] This enzyme catalyses the following chemical reaction
- 1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one + H2O 2,6-dihydroxypyridine + 4-methylaminobutanoate
The enzyme is present in the soil bacterium Arthrobacter nicotinovorans.
References
[edit]- ^ Gherna RL, Richardson SH, Rittenberg SC (September 1965). "The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine". The Journal of Biological Chemistry. 240 (9): 3669–74. PMID 5835946.
- ^ Sachelaru P, Schiltz E, Igloi GL, Brandsch R (December 2005). "An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans". Journal of Bacteriology. 187 (24): 8516–9. doi:10.1128/jb.187.24.8516-8519.2005. PMC 1317030. PMID 16321959.
External links
[edit]- 2,6-dihydroxypseudooxynicotine+hydrolase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)