April (9–13) | # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | 1 | April 6 | Yankees | 10–5 | Guthrie (1–0) | Sabathia (0–1) | | 48,607 | 1–0 | 2 | April 8 | Yankees | 7–5 | Uehara (1–0) | Wang (0–1) | Sherrill (1) | 22,856 | 2–0 | 3 | April 9 | Yankees | 11–2 | Burnett (1–0) | Simón (0–1) | | 28,534 | 2–1 | 4 | April 10 | Rays | 5–4 | Hendrickson (1–0) | Sonnanstine (0–1) | Sherrill (2) | 22,866 | 3–1 | 5 | April 11 | Rays | 6–0 | Guthrie (2–0) | Niemann (0–1) | | 15,108 | 4–1 | 6 | April 12 | Rays | 11–3 | Shields (1–1) | Eaton (0–1) | | 15,531 | 4–2 | 7 | April 13 | @ Rangers | 10–9 | Uehara (2–0) | Padilla (1–1) | Sherrill (3) | 12,184 | 5–2 | 8 | April 14 | @ Rangers | 7–5 (10) | Johnson (1–0) | Guardado (0–1) | | 14,041 | 6–2 | 9 | April 15 | @ Rangers | 19–6 | Benson (1–1) | Hendrickson (1–1) | | 17,539 | 6–3 | 10 | April 17 | @ Red Sox | 10–8 | Ramírez (1–0) | Báez (0–1) | Papelbon (3) | 38,266 | 6–4 | 11 | April 18 | @ Red Sox | 6–4 | Beckett (2–1) | Eaton (0–2) | Papelbon (4) | 37,559 | 6–5 | 12 | April 19 | @ Red Sox | 2–1 | Lester (1–2) | Uehara (2–1) | Saito (1) | 37,869 | 6–6 | 13 | April 20 | @ Red Sox | 12–1 | Masterson (1–0) | Hendrickson (1–2) | | 37,865 | 6–7 | 14 | April 21 | White Sox | 10–3 | Bergesen (1–0) | Contreras (0–3) | | 14,801 | 7–7 | 15 | April 22 | White Sox | 8–2 | Danks (2–0) | Guthrie (2–1) | | 10,868 | 7–8 | 16 | April 23 | White Sox | 6–2 | Eaton (1–2) | Colón (1–1) | | 11,723 | 8–8 | 17 | April 24 | Rangers | 5–4 | Wilson (1–2) | Sherrill (0–1) | Francisco (3) | 24,319 | 8–9 | 18 | April 25 | Rangers | 6–5 | Feldman (1–0) | Hendrickson (1–3) | Francisco (4) | 41,160 | 8–10 | 19 | April 26 | Rangers | 8–5 | Báez (1–1) | Jennings (0–1) | Sherrill (4) | 22,896 | 9–10 | 20 | April 27 | Rangers | 6–4 | Harrison (1–2) | Albers (0–1) | Francisco (5) | 10,621 | 9–11 | 21 | April 28 | Angels | 7–5 | Saunders (3–1) | Eaton (1–3) | Fuentes (4) | 11,857 | 9–12 | 22 | April 29 | Angels | 3–2 | Loux (1–2) | Uehara (2–2) | Fuentes (5) | 14,203 | 9–13 | May (14–15) | # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | 23 | May 1 | @ Blue Jays | 8–4 | Halladay (5–1) | Hendrickson (1–4) | | 20,202 | 9–14 | 24 | May 2 | @ Blue Jays | 5–4 (11) | Frasor (4–0) | Bass (0–1) | | 18,331 | 9–15 | 25 | May 3 | @ Blue Jays | 4–3 | Richmond (4–0) | Guthrie (2–2) | Downs (3) | 20,418 | 9–16 | 26 | May 4 | @ Rays | 8–4 | Báez (2–1) | Kazmir (3–3) | | 12,658 | 10–16 | 27 | May 5 | @ Rays | 6–3 | Garza (3–2) | Uehara (2–3) | Percival (4) | 13,174 | 10–17 | 28 | May 6 | Twins | 4–1 (6) | Bass (1–1) | Slowey (4–1) | | 10,566 | 11–17 | 29 | May 7 | Twins | 5–4 | Johnson (2–0) | Mijares (0–1) | Sherrill (5) | 11,399 | 12–17 | 30 | May 8 | Yankees | 4–0 | Sabathia (2–3) | Guthrie (2–3) | | 36,926 | 12–18 | 31 | May 9 | Yankees | 12–5 | Eaton (2–3) | Hughes (1–2) | | 41,825 | 13–18 | 32 | May 10 | Yankees | 5–3 | Chamberlain (2–1) | Johnson (2–1) | Rivera (6) | 33,290 | 13–19 | 33 | May 12 | Rays | 7–5 | Bass (2–1) | Sonnanstine (1–4) | Sherrill (6) | 17,122 | 14–19 | 34 | May 13 | Rays | 8–6 | Niemann (3–3) | Bergesen (1–1) | Howell (1) | 13,237 | 14–20 | 35 | May 14 | @ Royals | 9–5 | Guthrie (3–3) | Meche (2–4) | | 24,431 | 15–20 | 36 | May 15 | @ Royals | 8–1 | Greinke (7–1) | Eaton (2–4) | | 38,353 | 15–21 | 37 | May 16 | @ Royals | 3–2 | Hill (1–0) | Davies (2–2) | Sherrill (7) | 26,720 | 16–21 | 38 | May 17 | @ Royals | 7–4 | Cruz (3–0) | Johnson (2–2) | | 22,791 | 16–22 | 39 | May 19 | @ Yankees | 9–1 | Sabathia (4–3) | Bergesen (1–2) | | 42,838 | 16–23 | 40 | May 20 | @ Yankees | 11–4 | Hughes (2–2) | Guthrie (3–4) | Rivera (8) | 43,903 | 16–24 | 41 | May 21 | @ Yankees | 7–4 | Aceves (3–0) | Eaton (2–5) | Rivera (9) | 43,342 | 16–25 | 42 | May 22 | @ Nationals | 4–2 (12) | Báez (3–1) | Wells (0–2) | Sherrill (8) | 22,556 | 17–25 | 43 | May 23 | @ Nationals | 2–1 | Bass (3–1) | Tavárez (1–4) | Sherrill (9) | 31,883 | 18–25 | 44 | May 24 | @ Nationals | 8–5 | Villone (2–0) | Ray (0–1) | Hanrahan (5) | 30,880 | 18–26 | 45 | May 25 | Blue Jays | 4–1 | Guthrie (4–4) | Tallet (2–3) | Sherrill (10) | 24,904 | 19–26 | 46 | May 26 | Blue Jays | 7–2 | Berken (1–0) | Romero (2–1) | Johnson (1) | 10,130 | 20–26 | 47 | May 27 | Blue Jays | 12–10 (11) | Báez (4–1) | Wolfe (1–1) | | 13,713 | 21–26 | 48 | May 28 | Tigers | 5–1 | Hernandez (1–0) | Galarraga (3–5) | | 11,937 | 22–26 | 49 | May 29 | Tigers | 7–2 | Bergesen (2–2) | Willis (1–2) | | 42,704 | 23–26 | 50 | May 30 | Tigers | 6–3 | Verlander (6–2) | Albers (0–2) | Rodney (9) | 34,567 | 23–27 | 51 | May 31 | Tigers | 3–0 | Jackson (5–3) | Berken (1–1) | Rodney (10) | 32,233 | 23–28 | June (12–14) | # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | 52 | June 1 | @ Mariners | 1–0 | Hill (2–0) | Washburn (3–4) | Sherrill (11) | 16,979 | 24–28 | 53 | June 2 | @ Mariners | 8–2 | Bédard (4–2) | Hernandez (1–1) | | 17,978 | 24–29 | 54 | June 3 | @ Mariners | 3–2 | Aardsma (2–2) | Johnson (2–3) | | 18,650 | 24–30 | 55 | June 5 | @ Athletics | 9–1 | Braden (5–5) | Guthrie (4–5) | | 12,608 | 24–31 | 56 | June 6 | @ Athletics | 9–4 | Cahill (3–5) | Berken (1–2) | | 20,267 | 24–32 | 57 | June 7 | @ Athletics | 3–0 | Mazzaro (2–0) | Hill (2–1) | Bailey (4) | 17,208 | 24–33 | 58 | June 9 | Mariners | 3–1 | Bergesen (3–2) | Vargas (2–1) | Sherrill (12) | 17,358 | 25–33 | 59 | June 10 | Mariners | 4–1 | Hernández (6–3) | Guthrie (4–6) | Aardsma (10) | 12,770 | 25–34 | 60 | June 11 | Mariners | 6–3 | Olson (1–1) | Uehara (2–4) | Aardsma (11) | 12,260 | 25–35 | 61 | June 12 | Braves | 7–2 | Hanson (1–0) | Berken (1–3) | | 28,469 | 25–36 | 62 | June 13 | Braves | 8–4 | Bass (4–1) | O'Flaherty (1–1) | | 29,645 | 26–36 | 63 | June 14 | Braves | 11–2 | Bergesen (4–2) | Lowe (7–4) | | 26,770 | 27–36 | 64 | June 16 | Mets | 6–4 | Pelfrey (5–2) | Guthrie (4–7) | Rodríguez (17) | 20,626 | 27–37 | 65 | June 17 | Mets | 6–4 | Johnson (3–3) | Feliciano (2–2) | Sherrill (13) | 31,906 | 28–37 | 66 | June 18 | Mets | 5–4 | Albers (1–2) | Rodríguez (1–2) | | 23,009 | 29–37 | 67 | June 19 | @ Phillies | 7–2 | Hill (3–1) | Bastardo (2–2) | | 45,135 | 30–37 | 68 | June 20 | @ Phillies | 6–5 | Hendrickson (2–4) | Madson (2–3) | Sherrill (14) | 44,939 | 31–37 | 69 | June 21 | @ Phillies | 2–1 | Guthrie (5–7) | Hamels (4–3) | Sherrill (15) | 45,256 | 32–37 | 70 | June 23 | @ Marlins | 8–7 (12) | Badenhop (5–2) | Bass (4–2) | | 10,222 | 32–38 | 71 | June 24 | @ Marlins | 5–2 | Nolasco (4–6) | Berken (1–4) | Meyer (1) | 12,469 | 32–39 | 72 | June 25 | @ Marlins | 11–3 | West (3–2) | Hill (3–2) | | 12,822 | 32–40 | 73 | June 26 | Nationals | 11–1 | Bergesen (5–2) | Detwiler (0–4) | | 45,024 | 33–40 | 74 | June 27 | Nationals | 6–3 | Guthrie (6–7) | Martis (5–3) | Sherrill (16) | 39,633 | 34–40 | 75 | June 28 | Nationals | 5–3 | Lannan (5–5) | Hernandez (1–2) | MacDougal (3) | 25,068 | 34–41 | 76 | June 29 | Red Sox | 4–0 | Lester (7–6) | Berken (1–5) | Papelbon (19) | 36,548 | 34–42 | 77 | June 30 | Red Sox | 11–10 | Hendrickson (3–4) | Saito (2–1) | Sherrill (17) | 31,969 | 35–42 | July (9–16) | # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | 78 | July 1 | Red Sox | 6–5 (11) | Ramírez (5–2) | Báez (4–2) | Papelbon (20) | 29,391 | 35–43 | 79 | July 2 | @ Angels | 5–2 | Lackey (3–3) | Guthrie (6–8) | Fuentes (23) | 39,180 | 35–44 | 80 | July 3 | @ Angels | 6–4 | Hernandez (2–2) | Santana (1–4) | Sherrill (18) | 39,164 | 36–44 | 81 | July 4 | @ Angels | 11–4 | Bulger (3–1) | Báez (4–3) | | 41,764 | 36–45 | 82 | July 5 | @ Angels | 9–6 | Oliver (3–0) | Albers (1–3) | Fuentes (24) | 35,912 | 36–46 | 83 | July 6 | @ Mariners | 5–0 | Washburn (5–6) | Bergesen (5–3) | | 24,018 | 36–47 | 84 | July 7 | @ Mariners | 12–4 | Hendrickson (4–4) | Jakubauskas (5–6) | | 19,340 | 37–47 | 85 | July 8 | @ Mariners | 5–3 | Bass (5–2) | Aardsma (2–3) | Sherrill (19) | 27,040 | 38–47 | 86 | July 10 | Blue Jays | 2–0 | Cecil (3–1) | Berken (1–6) | Downs (9) | 30,574 | 38–48 | 87 | July 11 | Blue Jays | 4–3 (12) | Hendrickson (5–4) | Carlson (1–4) | | 28,281 | 39–48 | 88 | July 12 | Blue Jays | 4–2 | Bergesen (6–3) | Rzepczynski (0–1) | Sherrill (20) | 21,621 | 40–48 | 89 | July 17 | @ White Sox | 12–8 | Danks (8–6) | Berken (1–7) | | 32,013 | 40–49 | 90 | July 18 | @ White Sox | 4–3 | Buehrle (10–3) | Bergesen (6–4) | Jenks (21) | 32,881 | 40–50 | 91 | July 19 | @ White Sox | 10–2 | Guthrie (7–8) | Contreras (4–8) | | 32,069 | 41–50 | 92 | July 20 | @ Yankees | 2–1 | Aceves (6–1) | Johnson (3–4) | | 46,342 | 41–51 | 93 | July 21 | @ Yankees | 6–4 | Mitre (1–0) | Hill (3–3) | Rivera (27) | 45,589 | 41–52 | 94 | July 22 | @ Yankees | 6–4 | Burnett (9–4) | Berken (1–8) | Rivera (28) | 47,134 | 41–53 | 95 | July 24 | @ Red Sox | 3–1 | Penny (7–4) | Bergesen (6–5) | Papelbon (25) | 38,658 | 41–54 | 96 | July 25 | @ Red Sox | 7–2 | Lester (9–7) | Guthrie (7–9) | | 38,063 | 41–55 | 97 | July 26 | @ Red Sox | 6–2 | Hernandez (3–2) | Smoltz (1–4) | | 37,606 | 42–55 | 98 | July 27 | Royals | 5–3 | Tejeda (1–0) | Albers (1–4) | Soria (16) | 15,169 | 42–56 | 99 | July 28 | Royals | 4–3 (11) | Wright (1–3) | Báez (4–4) | Soria (17) | 21,545 | 42–57 | 100 | July 29 | Royals | 7–3 | Albers (2–4) | Tejeda (1–1) | Johnson (2) | 19,741 | 43–57 | 101 | July 30 | Royals | 7–3 | Bergesen (7–5) | Hochevar (6–4) | | 19,194 | 44–57 | 102 | July 31 | Red Sox | 6–5 | Smoltz (2–4) | Guthrie (7–10) | Papelbon (27) | 44,091 | 44–58 | August (10–20) | # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | 103 | August 1 | Red Sox | 4–0 | Beckett (13–4) | Hernandez (3–3) | | 49,384 | 44–59 | 104 | August 2 | Red Sox | 18–10 | Delcarmen (4–2) | Berken (1–9) | | 43,115 | 44–60 | 105 | August 3 | @ Tigers | 6–5 | Rodney (2–2) | Báez (4–5) | | 27,857 | 44–61 | 106 | August 4 | @ Tigers | 8–2 | Matusz (1–0) | Washburn (8–7) | | 29,295 | 45–61 | 107 | August 5 | @ Tigers | 4–2 | Jackson (8–5) | Guthrie (7–11) | Rodney (22) | 28,978 | 45–62 | 108 | August 6 | @ Tigers | 7–3 | Porcello (10–7) | Hernandez (3–4) | Lyon (1) | 31,165 | 45–63 | 109 | August 7 | @ Blue Jays | 7–5 | Berken (2–9) | Romero (10–5) | Johnson (3) | 30,795 | 46–63 | 110 | August 8 | @ Blue Jays | 3–2 (10) | Frasor (6–2) | Báez (4–6) | | 28,613 | 46–64 | 111 | August 9 | @ Blue Jays | 7–3 | Halladay (12–5) | Matusz (1–1) | | 27,464 | 46–65 | 112 | August 10 | Athletics | 9–1 | Gonzalez (4–2) | Guthrie (7–12) | | 14,688 | 46–66 | 113 | August 11 | Athletics | 3–2 | Hernandez (4–4) | Cahill (6–12) | Johnson (4) | 23,006 | 47–66 | 114 | August 12 | Athletics | 6–3 | Mazzaro (4–8) | Berken (2–10) | Bailey (17) | 19,128 | 47–67 | 115 | August 14 | Angels | 16–6 | Tillman (1–0) | Weaver (12–4) | | 25,836 | 48–67 | 116 | August 15 | Angels | 5–1 | Lackey (8–5) | Matusz (1–2) | Fuentes (33) | 28,770 | 48–68 | 117 | August 16 | Angels | 17–8 (13) | Bulger (6–1) | Bass (5–3) | | 26,529 | 48–69 | 118 | August 17 | Angels | 8–5 | Santana (6–6) | Hernandez (4–5) | Fuentes (34) | 18,460 | 48–70 | 119 | August 18 | @ Rays | 5–4 | Price (6–5) | Berken (2–11) | Howell (13) | 16,514 | 48–71 | 120 | August 19 | @ Rays | 3–1 | Niemann (11–5) | Tillman (1–1) | Howell (14) | 18,474 | 48–72 | 121 | August 20 | @ Rays | 8–7 | Matusz (2–2) | Shields (7–10) | Johnson (5) | 15,870 | 49–72 | 122 | August 21 | @ White Sox | 5–1 | Guthrie (8–12) | Floyd (10–8) | | 34,125 | 50–72 | 123 | August 22 | @ White Sox | 4–1 | Danks (11–8) | Hernandez (4–6) | Jenks (27) | 34,730 | 50–73 | 124 | August 23 | @ White Sox | 5–4 | Berken (3–11) | Buehrle (11–7) | Johnson (6) | 32,742 | 51–73 | 125 | August 24 | @ Twins | 2–1 | Baker (12–7) | Tillman (1–2) | Nathan (32) | 20,271 | 51–74 | 126 | August 25 | @ Twins | 7–6 | Mijares (2–2) | Mickolio (0–1) | | 23,696 | 51–75 | 127 | August 26 | @ Twins | 5–1 | Guthrie (9–12) | Blackburn (8–9) | | 28,446 | 52–75 | 128 | August 27 | Indians | 5–4 | Pérez (3–2) | Johnson (3–5) | Wood (17) | 13,991 | 52–76 | 129 | August 28 | Indians | 13–4 | Berken (4–11) | Carmona (3–9) | | 13,961 | 53–76 | 130 | August 29 | Indians | 5–3 | Pérez (4–2) | Ray (0–2) | Perez (1) | 24,358 | 53–77 | 131 | August 30 | Indians | 5–2 | Matusz (3–2) | Masterson (4–6) | Johnson (7) | 20,643 | 54–77 | 132 | August 31 | Yankees | 5–1 | Pettitte (12–6) | Guthrie (9–13) | Rivera (37) | 25,063 | 54–78 | September (6–20) | # | Date | Opponent | Score | Win | Loss | Save | Attendance | Record | 133 | September 1 | Yankees | 9–6 | Mitre (1–1) | Ray (0–3) | Rivera (38) | 25,782 | 54–79 | 134 | September 2 | Yankees | 10–2 | Sabathia (16–7) | Mickolio (0–2) | Hughes (2) | 21,126 | 54–80 | 135 | September 4 | Rangers | 5–1 | Feldman (15–4) | Tillman (1–3) | Feliz (2) | 15,557 | 54–81 | 136 | September 5 | Rangers | 5–4 | Matusz (4–2) | Millwood (10–9) | Johnson (8) | 18,028 | 55–81 | 137 | September 6 | Rangers | 7–0 | Guthrie (10–13) | Holland (7–10) | | 21,599 | 56–81 | 138 | September 8 | @ Red Sox | 10–0 | Buchholz (5–3) | Hernandez (4–7) | | 37,647 | 56–82 | 139 | September 9 | @ Red Sox | 7–5 | Wagner (1–0) | Albers (2–5) | Papelbon (35) | 37,712 | 56–83 | 140 | September 11 | @ Yankees | 10–4 | Tillman (2–3) | Marte (1–2) | Hendrickson (1) | 46,771 | 57–83 | 141 | September 12 | @ Yankees | 7–3 | Matusz (5–2) | Burnett (11–9) | | 46,497 | 58–83 | 142 | September 13 | @ Yankees | 13–3 | Sabathia (17–7) | Guthrie (10–14) | | 46,413 | 58–84 | 143 | September 14 | Rays | 8–4 | Price (8–7) | Hernandez (4–8) | | 10,628 | 58–85 | 144 | September 15 | Rays | 10–5 | Berken (5–11) | Niemann (12–6) | | 11,575 | 59–85 | 145 | September 16 | Rays | 4–2 | Johnson (4–5) | Springer (0–4) | | 10,548 | 60–85 | 146 | September 17 | Rays | 3–0 | Davis (1–1) | Hendrickson (5–5) | | 12,436 | 60–86 | 147 | September 18 | Red Sox | 3–1 | Buchholz (6–3) | Guthrie (10–15) | Papelbon (37) | 26,812 | 60–87 | 148 | September 19 | Red Sox | 11–5 | Lester (14–7) | Albers (2–6) | | 39,285 | 60–88 | 149 | September 20 | Red Sox | 9–3 | Matsuzaka (3–5) | Berken (5–12) | | 27,546 | 60–89 | 150 | September 21 | @ Blue Jays | 9–2 | Purcey (1–2) | Tillman (2–4) | | 11,598 | 60–90 | 151 | September 22 | @ Blue Jays | 6–5 (11) | Camp (2–6) | Sarfate (0–1) | | 11,869 | 60–91 | 152 | September 23 | @ Blue Jays | 7–3 | Richmond (7–10) | Guthrie (10–16) | | 13,743 | 60–92 | 153 | September 25 | @ Indians | 4–2 | Carmona (4–12) | Hernandez (4–9) | Wood (20) | 33,472 | 60–93 | 154 | September 26 | @ Indians | 9–8 | Wood (3–3) | Johnson (4–6) | | 31,749 | 60–94 | 155 | September 27 | @ Indians | 9–0 | Huff (11–8) | Tillman (2–5) | | 29,930 | 60–95 | 156 | September 28 | @ Rays | 7–6 | Cormier (3–3) | Ray (0–4) | Balfour (2) | 10,352 | 60–96 | 157 | September 29 | @ Rays | 3–1 | Davis (2–1) | Guthrie (10–17) | Balfour (3) | 10,349 | 60–97 | 158 | September 30 | @ Rays | 5–3 | Shields (11–12) | Hernandez (4–10) | Springer (1) | 10,554 | 60–98 | |