3-Nitrobenzanthrone
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Names | |
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Preferred IUPAC name 3-Nitro-7H-benzo[de]anthracen-7-one | |
Identifiers | |
3D model (JSmol) | |
ChemSpider | |
KEGG | |
PubChem CID | |
UNII | |
CompTox Dashboard (EPA) | |
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Properties | |
C17H9NO3 | |
Molar mass | 275.26 g/mol |
Melting point | 248 °C (478 °F; 521 K)[1] |
Hazards | |
Occupational safety and health (OHS/OSH): | |
Main hazards | extremely carcinogenic |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
3-Nitrobenzanthrone (3-nitro-7H-benz[de]anthracen-7-one) is a chemical compound emitted in diesel exhaust; it is a potent carcinogen.[2] It produced the highest score ever reported in the Ames test, a standard measure of the cancer-causing potential of toxic chemicals, far greater than the previous known strongest (1,8-dinitropyrene, which is also found in diesel exhaust).[3]
See also
[edit]References
[edit]- ^ Hansen, Tanja; Seidel, Albrecht; Borlak, Juergen (2007). "The environmental carcinogen 3-nitrobenzanthrone and its main metabolite 3-aminobenzanthrone enhance formation of reactive oxygen intermediates in human A549 lung epithelial cells". Toxicology and Applied Pharmacology. 221 (2): 222–234. doi:10.1016/j.taap.2007.03.003. PMID 17477947. S2CID 25295474.
- ^ Volker M. Arlt (2005). "3-Nitrobenzanthrone, a potential human cancer hazard in diesel exhaust and urban air pollution: a review of the evidence". Mutagenesis. 20 (6): 399–410. CiteSeerX 10.1.1.1001.7655. doi:10.1093/mutage/gei057. PMID 16199526.
- ^ Fred Pearce (Oct 25, 1997). "Devil in the diesel". New Scientist: 4.