AMP deaminase 2

AMPD2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAMPD2, PCH9, SPG63, adenosine monophosphate deaminase 2
External IDsOMIM: 102771; MGI: 88016; HomoloGene: 2979; GeneCards: AMPD2; OMA:AMPD2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001289719
NM_001289720
NM_028779
NM_001346665

RefSeq (protein)

NP_001276648
NP_001276649
NP_001333594
NP_083055

Location (UCSC)Chr 1: 109.62 – 109.63 MbChr 3: 107.98 – 107.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

AMP deaminase 2 is an enzyme that in humans is encoded by the AMPD2 gene.[5][6]

High AMPD2 expression levels correlate with poor patient outcome and a proliferative tumor phenotype in undifferentiated pleomorphic sarcoma (UPS). [7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116337Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027889Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mahnke-Zizelman DK, Sabina RL (Nov 1992). "Cloning of human AMP deaminase isoform E cDNAs. Evidence for a third AMPD gene exhibiting alternatively spliced 5'-exons". J Biol Chem. 267 (29): 20866–77. doi:10.1016/S0021-9258(19)36768-7. PMID 1400401.
  6. ^ "Entrez Gene: AMPD2 adenosine monophosphate deaminase 2 (isoform L)".
  7. ^ Orth MF, Gerke JS, Knösel T, Altendorf-Hofmann A, Musa J, Alba-Rubio R, et al. (September 2018). "Functional genomics identifies AMPD2 as a new prognostic marker for undifferentiated pleomorphic sarcoma". International Journal of Cancer. 144 (4): 859–867. doi:10.1002/ijc.31903. PMID 30267407.
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Further reading

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