Acidic leucine-rich nuclear phosphoprotein 32 family member A

ANP32A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JE0, 2JE1, 4XOS
Identifiers
Aliases	ANP32A, C15orf1, HPPCn, I1PP2A, LANP, MAPM, PHAP1, PHAPI, PP32, acidic nuclear phosphoprotein 32 family member A
External IDs	OMIM: 600832; MGI: 108447; HomoloGene: 133783; GeneCards: ANP32A; OMA:ANP32A - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	68,820,897 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	62,286,094 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; monocyte; ; paraflocculus of cerebellum; ; middle frontal gyrus; ; rectum; ; blood; ; C1 segment; ; inferior ganglion of vagus nerve; ; granulocyte;
	Top expressed in
	neural layer of retina; ; tail of embryo; ; genital tubercle; ; ventricular zone; ; granulocyte; ; maxillary prominence; ; dentate gyrus of hippocampal formation granule cell; ; mandibular prominence; ; superior frontal gyrus; ; migratory enteric neural crest cell;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA binding; histone binding;
Cellular component	cytoplasm; perinuclear region of cytoplasm; endoplasmic reticulum; nucleus; nucleoplasm;
Biological process	intracellular signal transduction; regulation of transcription, DNA-templated; nucleocytoplasmic transport; transcription, DNA-templated; regulation of mRNA stability; nucleosome assembly; regulation of apoptotic process; histone exchange;
	Sources:Amigo / QuickGO
Orthologs
	8125
	11737
	ENSG00000140350
	ENSMUSG00000032249
	P39687
	O35381
	NM_006305
	NM_009672
	NP_006296
	NP_033802
	Wikidata
View/Edit Human	View/Edit Mouse

Acidic leucine-rich nuclear phosphoprotein 32 family member A is a protein that in humans is encoded by the ANP32A gene.^[5]^[6]^[7] It is one of the targets of an oncomiR, MIRN21.

Interactions

Acidic leucine-rich nuclear phosphoprotein 32 family member A has been shown to interact with MAP1B,^[8] TAF1A^[9] and Protein SET.^[9]^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000140350 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032249 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chen TH, Brody JR, Romantsev FE, Yu JG, Kayler AE, Voneiff E, Kuhajda FP, Pasternack GR (March 1997). "Structure of pp32, an acidic nuclear protein which inhibits oncogene-induced formation of transformed foci". Mol Biol Cell. 7 (12): 2045–56. doi:10.1091/mbc.7.12.2045. PMC 276049. PMID 8970164.
^ Ulitzur N, Humbert M, Pfeffer SR (June 1997). "Mapmodulin: a possible modulator of the interaction of microtubule-associated proteins with microtubules". Proc Natl Acad Sci U S A. 94 (10): 5084–9. Bibcode:1997PNAS...94.5084U. doi:10.1073/pnas.94.10.5084. PMC 24635. PMID 9144194.
^ "Entrez Gene: ANP32A Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A".
^ Opal P, Garcia Jesus J, Propst Friedrich, Matilla Antoni, Orr Harry T, Zoghbi Huda Y (September 2003). "Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis". J. Biol. Chem. 278 (36): 34691–9. doi:10.1074/jbc.M302785200. ISSN 0021-9258. PMID 12807913.
^ ^a ^b Seo SB, McNamara P, Heo S, Turner A, Lane W S, Chakravarti D (January 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell. 104 (1): 119–30. doi:10.1016/S0092-8674(01)00196-9. ISSN 0092-8674. PMID 11163245.
^ Fan Z, Beresford Paul J, Zhang Dong, Lieberman Judy (April 2002). "HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A". Mol. Cell. Biol. 22 (8): 2810–20. doi:10.1128/MCB.22.8.2810-2820.2002. ISSN 0270-7306. PMC 133744. PMID 11909973.

External links

Human ANP32A genome location and ANP32A gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000140350 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032249 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8970164-5] Chen TH, Brody JR, Romantsev FE, Yu JG, Kayler AE, Voneiff E, Kuhajda FP, Pasternack GR (March 1997). "Structure of pp32, an acidic nuclear protein which inhibits oncogene-induced formation of transformed foci". Mol Biol Cell. 7 (12): 2045–56. doi:10.1091/mbc.7.12.2045. PMC 276049. PMID 8970164.

[pmid9144194-6] Ulitzur N, Humbert M, Pfeffer SR (June 1997). "Mapmodulin: a possible modulator of the interaction of microtubule-associated proteins with microtubules". Proc Natl Acad Sci U S A. 94 (10): 5084–9. Bibcode:1997PNAS...94.5084U. doi:10.1073/pnas.94.10.5084. PMC 24635. PMID 9144194.

[7] "Entrez Gene: ANP32A Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A".

[pmid12807913-8] Opal P, Garcia Jesus J, Propst Friedrich, Matilla Antoni, Orr Harry T, Zoghbi Huda Y (September 2003). "Mapmodulin/leucine-rich acidic nuclear protein binds the light chain of microtubule-associated protein 1B and modulates neuritogenesis". J. Biol. Chem. 278 (36): 34691–9. doi:10.1074/jbc.M302785200. ISSN 0021-9258. PMID 12807913.

[pmid11163245-9] Seo SB, McNamara P, Heo S, Turner A, Lane W S, Chakravarti D (January 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell. 104 (1): 119–30. doi:10.1016/S0092-8674(01)00196-9. ISSN 0092-8674. PMID 11163245.

[pmid11909973-10] Fan Z, Beresford Paul J, Zhang Dong, Lieberman Judy (April 2002). "HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A". Mol. Cell. Biol. 22 (8): 2810–20. doi:10.1128/MCB.22.8.2810-2820.2002. ISSN 0270-7306. PMC 133744. PMID 11909973.

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Acidic leucine-rich nuclear phosphoprotein 32 family member A

Interactions

See also

References

Further reading

External links