Protein-coding gene in the species Homo sapiens
AP-1 complex subunit gamma-like 2 is a protein that in humans is encoded by the AP1G2 gene .[ 5] [ 6] [ 7]
Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. This protein along with the complex is thought to function at some trafficking step in the complex pathways between the trans-Golgi network and the cell surface. There are two alternatively spliced transcript variants of this gene encoding the same protein.[ 7]
AP1G2 has been shown to interact with NEDD4 .[ 8]
^ a b c GRCh38: Ensembl release 89: ENSG00000213983 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040701 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Takatsu H, Sakurai M, Shin HW, Murakami K, Nakayama K (Oct 1998). "Identification and characterization of novel clathrin adaptor-related proteins" . J Biol Chem . 273 (38): 24693–700. doi :10.1074/jbc.273.38.24693 PMID 9733768 . ^ Lewin DA, Sheff D, Ooi CE, Whitney JA, Yamamoto E, Chicione LM, Webster P, Bonifacino JS, Mellman I (Oct 1998). "Cloning, expression, and localization of a novel gamma-adaptin-like molecule". FEBS Lett . 435 (2–3): 263–8. Bibcode :1998FEBSL.435..263L . doi :10.1016/S0014-5793(98)01083-7 . PMID 9762922 . 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"Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity" . Proc. Natl. Acad. Sci. U.S.A . 95 (19): 11229–34. Bibcode :1998PNAS...9511229C . doi :10.1073/pnas.95.19.11229 PMC 21624 PMID 9736718 . Bresnahan PA, Yonemoto W, Ferrell S, et al. (1999). "A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor" . Curr. Biol . 8 (22): 1235–8. Bibcode :1998CBio....8.1235B . doi :10.1016/S0960-9822(07)00517-9 PMID 9811606 . Greenberg M, DeTulleo L, Rapoport I, et al. (1999). "A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4" . Curr. Biol . 8 (22): 1239–42. Bibcode :1998CBio....8.1239G . doi :10.1016/S0960-9822(07)00518-0 PMID 9811611 . Berlioz-Torrent C, Shacklett BL, Erdtmann L, et al. (1999). "Interactions of the cytoplasmic domains of human and simian retroviral transmembrane proteins with components of the clathrin adaptor complexes modulate intracellular and cell surface expression of envelope glycoproteins" . J. Virol . 73 (2): 1350–61. doi :10.1128/JVI.73.2.1350-1361.1999 . PMC 103959 PMID 9882340 . Page LJ, Sowerby PJ, Lui WW, Robinson MS (1999). "Gamma-synergin: an EH domain-containing protein that interacts with gamma-adaptin" . J. Cell Biol . 146 (5): 993–1004. doi :10.1083/jcb.146.5.993 . PMC 2169493 PMID 10477754 . Wyss S, Berlioz-Torrent C, Boge M, et al. (2001). "The highly conserved C-terminal dileucine motif in the cytosolic domain of the human immunodeficiency virus type 1 envelope glycoprotein is critical for its association with the AP-1 clathrin adaptor [correction of adapter]" . J. Virol . 75 (6): 2982–92. doi :10.1128/JVI.75.6.2982-2992.2001 . PMC 115924 PMID 11222723 . Hartmann-Stühler C, Prange R (2001). "Hepatitis B virus large envelope protein interacts with gamma2-adaptin, a clathrin adaptor-related protein" . J. Virol . 75 (11): 5343–51. doi :10.1128/JVI.75.11.5343-5351.2001 . PMC 114939 PMID 11333915 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Janvier K, Craig H, Hitchin D, et al. (2003). "HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes" . J. Biol. Chem . 278 (10): 8725–32. doi :10.1074/jbc.M210115200 PMID 12486136 . Mattera R, Arighi CN, Lodge R, et al. (2003). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex" . EMBO J . 22 (1): 78–88. doi :10.1093/emboj/cdg015 . PMC 140067 PMID 12505986 . Mattera R, Ritter B, Sidhu SS, et al. (2004). "Definition of the consensus motif recognized by gamma-adaptin ear domains" . J. Biol. Chem . 279 (9): 8018–28. doi :10.1074/jbc.M311873200 PMID 14665628 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation" . Genome Res . 14 (7): 1315–23. doi :10.1101/gr.2122004 . PMC 442147 PMID 15231747 . Coleman SH, Van Damme N, Day JR, et al. (2005). "Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes" . J. Virol . 79 (4): 2066–78. doi :10.1128/JVI.79.4.2066-2078.2005 . PMC 546596 PMID 15681409 .
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