Allolactose

Allolactose
Names
	IUPAC name 6-O-β-D-Galactopyranosyl-D-glucopyranose
	Systematic IUPAC name (3R,4S,5S,6R)-6-[[(2R,3R,4S,5R,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxane-2,3,4,5-tetrol
	Other names 6-O-β-D-Galactopyranosyl-D-glucose; β-D-Galactopyranosyl (1→6)-D-glucose
Identifiers
CAS Number	28447-39-4 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:36229 ;
ChemSpider	4957195 ;
PubChem CID	67375559;
UNII	C7B2C5KXF9 ;
CompTox Dashboard (EPA)	DTXSID80893952 ;
	InChI InChI=1S/C12H22O11/c13-1-3-5(14)8(17)10(19)12(23-3)21-2-4-6(15)7(16)9(18)11(20)22-4/h3-20H,1-2H2/t3-,4-,5+,6-,7+,8+,9-,10-,11?,12-/m1/s1 Key: DLRVVLDZNNYCBX-VDGMBKLFSA-N ; InChI=1/C12H22O11/c13-1-3-5(14)8(17)10(19)12(23-3)21-2-4-6(15)7(16)9(18)11(20)22-4/h3-20H,1-2H2/t3-,4-,5+,6-,7+,8+,9-,10-,11?,12-/m1/s1 Key: DLRVVLDZNNYCBX-VDGMBKLFBT;
	SMILES O[C@H]1[C@H](O)[C@H](OC(O)[C@@H]1O)CO[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O;
Properties
Chemical formula	C12H22O11
Molar mass	342.296 g/mol
Density	1.768 g/mL
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Allolactose is a disaccharide similar to lactose. It consists of the monosaccharides D-galactose and D-glucose linked through a β1-6 glycosidic linkage instead of the β1-4 linkage of lactose. It may arise from the occasional transglycosylation of lactose by β-galactosidase.

It is an inducer of the lac operon in Escherichia coli and many other enteric bacteria. It binds to a subunit of the tetrameric lac repressor, which results in conformational changes and reduces the binding affinity of the lac repressor to the lac operator, thereby dissociating it from the lac operator. The absence of the repressor allows the transcription of the lac operon to proceed. A non-hydrolyzable analog of allolactose, isopropyl β-D-1-thiogalactopyranoside (IPTG), is normally used in molecular biology to induce the lac operon.

External links

allolactose at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Illustration of function

Names


IUPAC name 6-O-β-D-Galactopyranosyl-D-glucopyranose
Systematic IUPAC name (3R,4S,5S,6R)-6-[[(2R,3R,4S,5R,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxane-2,3,4,5-tetrol
Other names 6-O-β-D-Galactopyranosyl-D-glucose; β-D-Galactopyranosyl (1→6)-D-glucose
Identifiers
CAS Number	28447-39-4^N
3D model (JSmol)	Interactive image
ChEBI	CHEBI:36229^Y
ChemSpider	4957195^Y
PubChem CID	67375559
UNII	C7B2C5KXF9^Y
CompTox Dashboard (EPA)	DTXSID80893952
InChI InChI=1S/C12H22O11/c13-1-3-5(14)8(17)10(19)12(23-3)21-2-4-6(15)7(16)9(18)11(20)22-4/h3-20H,1-2H2/t3-,4-,5+,6-,7+,8+,9-,10-,11?,12-/m1/s1^Y Key: DLRVVLDZNNYCBX-VDGMBKLFSA-N^Y InChI=1/C12H22O11/c13-1-3-5(14)8(17)10(19)12(23-3)21-2-4-6(15)7(16)9(18)11(20)22-4/h3-20H,1-2H2/t3-,4-,5+,6-,7+,8+,9-,10-,11?,12-/m1/s1 Key: DLRVVLDZNNYCBX-VDGMBKLFBT
SMILES O[C@H]1[C@H](O)[C@H](OC(O)[C@@H]1O)CO[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O
Properties
Chemical formula	C₁₂H₂₂O₁₁
Molar mass	342.296 g/mol
Density	1.768 g/mL
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references

Allolactose

See also

External links