Andrew N. J. McKenzie

Andrew McKenzie
FRS FMedSci
Andrew McKenzie FRS FMedSci
	McKenzie in 2017
Born	Andrew Neil James McKenzie
Education	University of London (PhD)
	Scientific career
Fields	Immunology; Autoimmunity; Molecular biology
Institutions	Laboratory of Molecular Biology; University of Cambridge; National Institute for Medical Research
Thesis	Cellular and humoral aspects of the immune response of the larval stages of Calliphora vomitoria L. (Insecta: Diptera) (1988)
Website	www2.mrc-lmb.cam.ac.uk/group-leaders/h-to-m/andrew-mckenzie/

Andrew Neil James McKenzie is a British molecular biologist who is a group leader in the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB).^[2]

Education

McKenzie was educated at the University of London where he was awarded a PhD for research on the immune response of the bluebottle fly (Calliphora vomitoria),^[3] covering both humoral immunity and cell-mediated immunity.

Research and career

McKenzie's research investigates how the innate immune system and adaptive immune system protect the body from infection, but can also lead to inflammation and pathology.^[4] He has defined and characterised how biological networks orchestrate responses to pathogens and how dysregulation of these biological pathways can lead to diseases such as asthma and allergy.^[4]^[5]

His identification of the cytokine Interleukin 13 and the subsequent unearthing of its central role in allergic asthma led to his discovery of type-2 innate lymphoid cells (ILC2).^[6]^[7] These cells secrete large quantities of cytokines and represent a new druggable biological target for intervention in inflammation and infection.^[4]

Awards and honours

McKenzie was elected a Fellow of the Royal Society (FRS) in 2017^[4] and a Fellow of the Academy of Medical Sciences (FMedSci) in 2011.^[8]

References

^ McKenzie, Andrew N.J.; Ely, Barry; Sanderson, Colin J. (1991). "Mutated interleukin-5 monomers are biologically inactive". Molecular Immunology. 28 (1–2): 155–158. doi:10.1016/0161-5890(91)90099-6. ISSN 0161-5890. PMID 1901378.
^ Andrew N. J. McKenzie publications indexed by the Scopus bibliographic database. (subscription required)
^ McKenzie, Andrew Neil James (1988). Cellular and humoral aspects of the immune response of the larval stages of Calliphora vomitoria L. (Insecta: Diptera). london.ac.uk (PhD thesis). University of London. OCLC 940318709.
^ ^a ^b ^c ^d Anon (2017). "Dr Andrew McKenzie FMedSci FRS". royalsociety.org. London: Royal Society. Archived from the original on 2017-05-05. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
“All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --"Terms, conditions and policies | Royal Society". Archived from the original on 2016-11-11. Retrieved 2017-08-18.{{cite web}}: CS1 maint: bot: original URL status unknown (link)
^ Neill, Daniel R.; Wong, See Heng; Bellosi, Agustin; Flynn, Robin J.; Daly, Maria; Langford, Theresa K. A.; Bucks, Christine; Kane, Colleen M.; Fallon, Padraic G.; Pannell, Richard; Jolin, Helen E.; McKenzie, Andrew N. J. (2010). "Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity". Nature. 464 (7293): 1367–1370. doi:10.1038/nature08900. ISSN 0028-0836. PMC 2862165. PMID 20200518.
^ Spits, Hergen; Artis, David; Colonna, Marco; Diefenbach, Andreas; Di Santo, James P.; Eberl, Gerard; Koyasu, Shigeo; Locksley, Richard M.; McKenzie, Andrew N. J.; Mebius, Reina E.; Powrie, Fiona; Vivier, Eric (2013). "Innate lymphoid cells — a proposal for uniform nomenclature". Nature Reviews Immunology. 13 (2): 145–149. doi:10.1038/nri3365. ISSN 1474-1733. PMID 23348417. (subscription required)
^ Newland, Stephen A.; Mohanta, Sarajo; Clément, Marc; Taleb, Soraya; Walker, Jennifer A.; Nus, Meritxell; Sage, Andrew P.; Yin, Changjun; Hu, Desheng; Kitt, Lauren L.; Finigan, Alison J.; Rodewald, Hans-Reimer; Binder, Christoph J.; McKenzie, Andrew N. J.; Habenicht, Andreas J.; Mallat, Ziad (2017). "Type-2 innate lymphoid cells control the development of atherosclerosis in mice". Nature Communications. 8: 15781. doi:10.1038/ncomms15781. ISSN 2041-1723. PMC 5467269. PMID 28589929.
^ "Andrew McKenzie". Retrieved 22 January 2022.

[McKenzieEly1991-1] McKenzie, Andrew N.J.; Ely, Barry; Sanderson, Colin J. (1991). "Mutated interleukin-5 monomers are biologically inactive". Molecular Immunology. 28 (1–2): 155–158. doi:10.1016/0161-5890(91)90099-6. ISSN 0161-5890. PMID 1901378.

[scopus-2] Andrew N. J. McKenzie publications indexed by the Scopus bibliographic database. (subscription required)

[phd-3] McKenzie, Andrew Neil James (1988). Cellular and humoral aspects of the immune response of the larval stages of Calliphora vomitoria L. (Insecta: Diptera). london.ac.uk (PhD thesis). University of London. OCLC 940318709.

[frs-4] Anon (2017). "Dr Andrew McKenzie FMedSci FRS". royalsociety.org. London: Royal Society. Archived from the original on 2017-05-05. One or more of the preceding sentences incorporates text from the royalsociety.org website where:
“All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License.” --"Terms, conditions and policies | Royal Society". Archived from the original on 2016-11-11. Retrieved 2017-08-18.{{cite web}}: CS1 maint: bot: original URL status unknown (link)

[NeillWong2010-5] Neill, Daniel R.; Wong, See Heng; Bellosi, Agustin; Flynn, Robin J.; Daly, Maria; Langford, Theresa K. A.; Bucks, Christine; Kane, Colleen M.; Fallon, Padraic G.; Pannell, Richard; Jolin, Helen E.; McKenzie, Andrew N. J. (2010). "Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity". Nature. 464 (7293): 1367–1370. doi:10.1038/nature08900. ISSN 0028-0836. PMC 2862165. PMID 20200518.

[SpitsArtis2013-6] Spits, Hergen; Artis, David; Colonna, Marco; Diefenbach, Andreas; Di Santo, James P.; Eberl, Gerard; Koyasu, Shigeo; Locksley, Richard M.; McKenzie, Andrew N. J.; Mebius, Reina E.; Powrie, Fiona; Vivier, Eric (2013). "Innate lymphoid cells — a proposal for uniform nomenclature". Nature Reviews Immunology. 13 (2): 145–149. doi:10.1038/nri3365. ISSN 1474-1733. PMID 23348417. (subscription required)

[NewlandMohanta2017-7] Newland, Stephen A.; Mohanta, Sarajo; Clément, Marc; Taleb, Soraya; Walker, Jennifer A.; Nus, Meritxell; Sage, Andrew P.; Yin, Changjun; Hu, Desheng; Kitt, Lauren L.; Finigan, Alison J.; Rodewald, Hans-Reimer; Binder, Christoph J.; McKenzie, Andrew N. J.; Habenicht, Andreas J.; Mallat, Ziad (2017). "Type-2 innate lymphoid cells control the development of atherosclerosis in mice". Nature Communications. 8: 15781. doi:10.1038/ncomms15781. ISSN 2041-1723. PMC 5467269. PMID 28589929.

[8] "Andrew McKenzie". Retrieved 22 January 2022.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

v t e Fellows of the Royal Society elected in 2017
Fellows	Yves-Alain Barde Tony Bell Christopher Bishop Neil Burgess Keith Beven Wendy Bickmore Krishna Chatterjee James Durrant Warren East Tim Elliott Anne Ferguson-Smith Jonathan Gregory Mark Gross Roy Harrison Gabriele Hegerl Eddie Holmes Richard Houlston Yvonne Jones Subhash Khot Julia King Stafford Lightman Yadvinder Malhi Andrew McKenzie Gerard Milburn Anne Neville Alison Noble Andrew Orr-Ewing David Owen Lawrence Paulson Josephine Pemberton Sandu Popescu Sarah Price Anne Ridley David Rubinsztein Gavin Salam Nigel Shadbolt Angus Silver Gordon Slade Pete Smith Nicola Spaldin Jonathan Stoye John Sutherland J. Roy Taylor Jenny Thomas Patrick Vallance Susanne von Caemmerer Hugh Watkins Roger Williams Ken Wolfe Andy Woods
Honorary	David Neuberger
Foreign	Max Cooper Whitfield Diffie Robert Grubbs Hideo Hosono Marcia McNutt Ginés Morata Robert Ritchie Thomas Südhof David Tilman Susan Wessler