Annexin A9

ANXA9
Identifiers
AliasesANXA9, ANX31, annexin A9
External IDsOMIM: 603319; MGI: 1923711; HomoloGene: 2643; GeneCards: ANXA9; OMA:ANXA9 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003568

NM_001085383
NM_023628
NM_001379545
NM_001379546

RefSeq (protein)

NP_003559

NP_001078852
NP_076117
NP_001366474
NP_001366475

Location (UCSC)Chr 1: 150.98 – 151 MbChr 3: 95.2 – 95.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Annexin A9 is a protein that in humans is encoded by the ANXA9 gene.[5][6][7]

Function

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The annexins are a family of calcium-dependent phospholipid-binding proteins. Members of the annexin family contain 4 internal repeat domains, each of which includes a type II calcium-binding site. The calcium-binding sites are required for annexins to aggregate and cooperatively bind anionic phospholipids and extracellular matrix proteins. This gene encodes a divergent member of the annexin protein family in which all four homologous type II calcium-binding sites in the conserved tetrad core contain amino acid substitutions that ablate their function. However, structural analysis suggests that the conserved putative ion channel formed by the tetrad core is intact.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143412Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015702Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Morgan RO, Fernandez MP (Sep 1998). "Expression profile and structural divergence of novel human annexin 31". FEBS Letters. 434 (3): 300–4. doi:10.1016/S0014-5793(98)00997-1. PMID 9742942. S2CID 13751169.
  6. ^ Morgan RO, Bell DW, Testa JR, Fernandez MP (Feb 1999). "Human annexin 31 genetic mapping and origin". Gene. 227 (1): 33–8. doi:10.1016/S0378-1119(98)00597-6. PMID 9931420.
  7. ^ a b "Entrez Gene: ANXA9 annexin A9".
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Further reading

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