Baculoviral IAP repeat-containing protein 3

BIRC3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2UVL, 3EB5, 3EB6, 3M0A, 3M0D
Identifiers
Aliases	BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2, baculoviral IAP repeat containing 3, IAP-1
External IDs	OMIM: 601721; MGI: 1197007; HomoloGene: 899; GeneCards: BIRC3; OMA:BIRC3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q22.2 Start 102,317,450 bp[1] End 102,339,403 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A1 Start 7,848,700 bp[2] End 7,873,187 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in appendix epithelium of nasopharynx cartilage tissue lymph node spleen gallbladder granulocyte mucosa of sigmoid colon palpebral conjunctiva tonsil Top expressed in secondary oocyte zygote primary oocyte mesenteric lymph nodes granulocyte spleen prostate egg cell lobe of prostate thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process protein binding ubiquitin-protein transferase activity transferase activity ubiquitin protein ligase activity Cellular component cytoplasm nucleoplasm membrane raft nucleus cytosol protein-containing complex Biological process regulation of apoptotic process regulation of nucleotide-binding oligomerization domain containing signaling pathway regulation of innate immune response regulation of toll-like receptor signaling pathway negative regulation of necroptotic process inhibition of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity regulation of RIG-I signaling pathway regulation of tumor necrosis factor-mediated signaling pathway negative regulation of apoptotic process tumor necrosis factor-mediated signaling pathway mitotic spindle assembly cell surface receptor signaling pathway NIK/NF-kappaB signaling spermatogenesis regulation of inflammatory response positive regulation of I-kappaB kinase/NF-kappaB signaling I-kappaB kinase/NF-kappaB signaling positive regulation of protein ubiquitination apoptotic process protein ubiquitination protein deubiquitination regulation of necroptotic process protein heterooligomerization MyD88-independent toll-like receptor signaling pathway TRIF-dependent toll-like receptor signaling pathway negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 330 11796 Ensembl ENSG00000023445 ENSMUSG00000032000 UniProt Q13489 O08863 RefSeq (mRNA) NM_001165 NM_182962 NM_007464 RefSeq (protein) NP_001156 NP_892007 NP_031490 Location (UCSC) Chr 11: 102.32 – 102.34 Mb Chr 9: 7.85 – 7.87 Mb PubMed search [3] [4]
Wikidata
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Baculoviral IAP repeat-containing protein3 (also known as cIAP2) is a protein that in humans is encoded by the BIRC3 gene.^[5][6]

cIAP2 is a member of the inhibitor of apoptosis family that inhibit apoptosis by interfering with the activation of caspases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The cIAP2 protein contains three BIR domains, a UBA domain, a CARD domain and a RING finger domain. Transcript variants encoding the same isoform have been identified.^[7]

Baculoviral IAP repeat-containing protein 3 has been shown to interact with:

• CASP9,^[8]
• RIPK1,^[9]
• TRAF1,^[10][11]
• TRAF2,^{[10][11][12][13]} and
• UBE2D2.^[14]

• Human BIRC3 genome location and BIRC3 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: Q13489 (Baculoviral IAP repeat-containing protein 3) at the PDBe-KB.