BTBD9

BTBD9
Identifiers
Aliases	BTBD9, dJ322I12.1, BTB domain containing 9
External IDs	OMIM: 611237; MGI: 1916625; HomoloGene: 14995; GeneCards: BTBD9; OMA:BTBD9 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.2 Start 38,168,451 bp[1] End 38,640,148 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 A3.3 Start 30,434,498 bp[2] End 30,795,462 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell mucosa of paranasal sinus bone marrow cells sural nerve tibialis anterior muscle Achilles tendon middle temporal gyrus lower lobe of lung prefrontal cortex epithelium of nasopharynx Top expressed in interventricular septum dentate gyrus of hippocampal formation granule cell otolith organ utricle spermatid neural layer of retina neural tube hippocampus proper visual cortex primary visual cortex More reference expression data BioGPS n/a
Gene ontology Molecular function ubiquitin protein ligase binding Cellular component cytoplasm SCF ubiquitin ligase complex Biological process long-term memory serotonin metabolic process circadian sleep/wake cycle, non-REM sleep sensory perception of temperature stimulus multicellular organismal iron ion homeostasis regulation of synaptic vesicle endocytosis proteasome-mediated ubiquitin-dependent protein catabolic process circadian behavior modulation of chemical synaptic transmission regulation of proteolysis adult locomotory behavior Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114781 224671 Ensembl ENSG00000183826 ENSMUSG00000062202 UniProt Q96Q07 Q8C726 RefSeq (mRNA) NM_001099272 NM_001172418 NM_052893 NM_152733 NM_027060 NM_172618 RefSeq (protein) NP_001092742 NP_001165889 NP_443125 NP_689946 NP_081336 NP_766206 Location (UCSC) Chr 6: 38.17 – 38.64 Mb Chr 17: 30.43 – 30.8 Mb PubMed search [3] [4]
Wikidata
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BTB domain containing 9 is a protein that in humans is encoded by the BTBD9 gene.

BTBD9 is in a subgroup of BTB(POZ) proteins, which contribute to the forming of limbs and determination of cell fate in developing Drosophila melanogaster.^[5] BTB(POZ) proteins also play a role in cellular functions such as: cytoskeleton regulation, transcription regulation, the gating and assembly of ion channels, and ubiquitination of proteins. BTBD9 is highly expressed throughout the brain and shows variable levels of expression in most other body tissues.^[6][7]

The gene is located on the short arm of chromosome 6 and the domain contains eight exons and seven introns. The chromosome 6 locational domain that codes for BTB(POZ) proteins is understood to contain genes encoding protein-protein interactions.^[8] BTBD9 is a protein located in cellular cytosol and also expressed within Human embryonic kidney cell lineages.^[9] There is also evidence suggesting that BTBD9 is highly expressed within the human nervous system from comparison analysis to Drosophila and human cell studies.^[9]

There are extensive homologs to BTBD9 which allow for the use of animal models in deciphering its functions and interactions. The BTBD9 homolog Btbd9 is extensively expressed in the central nervous system of adult mice including the thalamus, sub-thalamic nuclei, cerebral cortex, cerebellum, hippocampus, and caudate nucleus.^[10] The Drosophila homolog dBTBD9, was shown to regulate dopamine levels in the Drosophila brain and iron regulation in human cell-lines.^[9]

A recent study using Btbd9 knockout mice argued that BTBD9 is involved in synaptic plasticity, learning and memory, and protein alterations associated with vesicle recycling and endocytosis.^[11]

There is some evidence that BTBD9 may be associated with Restless legs syndrome.^[8] However, there is not a known mutation of the BTBD9 gene that is responsible for the onset of the RLS.^[12] Mutations to BTBD9 are positively correlated with characteristic symptoms of Restless leg syndrome such as decreased dopamine levels, increased movement, and disrupted sleep patterns.^[8] The overrepresentation of single nucleotide polymorphisms expressed in BTBD9 may be associated with Restless legs syndrome and nighttime leg movements.^[8] Single nucleotide polymorphisms in BTBD9 that have been linked to Restless leg syndrome are also correlated with Tourette’s Syndrome that doesn’t present with Obsessive Compulsive Disorder.^[13] One scientific review regarding Restless Legs Syndrome expressed that Restless Legs Syndrome is a complex syndrome that has many risk factor indicators including the presence of the BTBD9 gene.^[14] Drosophila CG18126 gene loss was found to be correlated to sleep lost behavior within fruit fly experiments.^[9] The BTBD9 gene through the use of iron regulatory protein-2 in human cell line is found to be associated with the regulation of iron levels in human cells.^[9] One scientific review discussed how the iron level association found in human cell lines was also present in animal phenotypes.^[14] These model organisms could have normal iron levels present throughout the body even when the dopamine neural pathways had below normal iron levels within the brain^[14] due to the BTBD9 presence. One study was able to look at a single nucleotide polymorphism in BTBD9. This mutation can be contributed to these various health issues.^[15] The BTBD9 gene has also been linked to blood anemia in a study.^[16] The study linked a genetic marker in the BTBD9 gene with anemia in blood donors. It was found that higher ferritin levels could be connected to a variant in the allele (G) in the BTBD9 gene. The study was only conducted with Australian blood donors. The high ferritin levels indicated a contribution to the variant allel (G) while decreased ferritin levels indicate the BTBD9 gene is being over expressed.^[16]