Bisdisulizole disodium

Bisdisulizole disodium
Names
	Preferred IUPAC name Disodium 2,2′-(1,4-phenylene)bis(6-sulfo-1H-1,3-benzimidazole-4-sulfonate)
Identifiers
CAS Number	180898-37-7 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL2111085 ;
ChemSpider	9333274 ;
ECHA InfoCard	100.121.951
PubChem CID	11158166;
UNII	Z99XUY03BK ;
CompTox Dashboard (EPA)	DTXSID001021219 ;
	InChI InChI=1S/C20H14N4O12S4.2Na/c25-37(26,27)11-5-13-17(15(7-11)39(31,32)33)23-19(21-13)9-1-2-10(4-3-9)20-22-14-6-12(38(28,29)30)8-16(18(14)24-20)40(34,35)36;;/h1-8H,(H,21,23)(H,22,24)(H,25,26,27)(H,28,29,30)(H,31,32,33)(H,34,35,36);;/q;2+1/p-2 Key: GLCJMPWWQKKJQZ-UHFFFAOYSA-L ; InChI=1/C20H14N4O12S4.2Na/c25-37(26,27)11-5-13-17(15(7-11)39(31,32)33)23-19(21-13)9-1-2-10(4-3-9)20-22-14-6-12(38(28,29)30)8-16(18(14)24-20)40(34,35)36;;/h1-8H,(H,21,23)(H,22,24)(H,25,26,27)(H,28,29,30)(H,31,32,33)(H,34,35,36);;/q;2+1/p-2 Key: GLCJMPWWQKKJQZ-NUQVWONBAQ;
	SMILES C1=CC(=CC=C1C2=NC3=C(C=C(C=C3N2)S(=O)(=O)O)S(=O)(=O)[O-])C4=NC5=C(C=C(C=C5N4)S(=O)(=O)O)S(=O)(=O)[O-].[Na+].[Na+];
Properties
Chemical formula	C20H12N4Na2O12S4
Molar mass	674.55 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Bisdisulizole disodium (INN^[1]/USAN,^[2] trade name Neo Heliopan AP, INCI disodium phenyl dibenzimidazole tetrasulfonate) is a water-soluble organic compound which is added to sunscreen products to absorb UVA rays. It is marketed by Symrise.

The use of bisdisulizole disodium has been approved in the European Union (since the year 2000)^[3] and other parts of the world up to 10% in sunscreen formulations,^[4]^[5]^[6] while it is not approved in the United States.

References

^ http://ec.europa.eu/enterprise/cosmetics/cosing/index.cfm?fuseaction=search.detailsPDF&id=75792^{[permanent dead link‍]}
^ "Statement on a nonproprietary name adopted by the USAN Council: Bisdisulizole disodium" (PDF). American Medical Association. April 4, 2006. Retrieved 2008-01-08.
^ Osstervalder U, Luther H, Herzog B (2001). "Über den Lichtschutzfaktor hinaus - neue effiziente und photostabile UVA-Filter". Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz (in German). 44 (5): 463–70. doi:10.1007/s001030170019. S2CID 36985446.
^ "10. Sunscreens" (PDF). Australian regulatory guidelines for OTC medicines. Commonwealth Department of Health and Ageing, Therapeutic Goods Administration. July 1, 2003. p. 14. Archived from the original (PDF) on August 31, 2007. Retrieved 2008-01-08.
^ "Symrise UV protection products" (PDF). Symrise. Archived from the original (PDF) on 2008-08-21. Retrieved 2008-08-10.
^ "Cosmetic Products Regulation, Annex VI - Allowed UV Filters". ECHA. Retrieved 2023-08-15.

This dermatologic drug article is a stub. You can help Wikipedia by expanding it.

[1] ttp://ec.europa.eu/enterprise/cosmetics/cosing/index.cfm?fuseaction=search.detailsPDF&id=75792^{[permanent dead link‍]}

[2] "Statement on a nonproprietary name adopted by the USAN Council: Bisdisulizole disodium" (PDF). American Medical Association. April 4, 2006. Retrieved 2008-01-08.

[3] Osstervalder U, Luther H, Herzog B (2001). "Über den Lichtschutzfaktor hinaus - neue effiziente und photostabile UVA-Filter". Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz (in German). 44 (5): 463–70. doi:10.1007/s001030170019. S2CID 36985446.

[4] "10. Sunscreens" (PDF). Australian regulatory guidelines for OTC medicines. Commonwealth Department of Health and Ageing, Therapeutic Goods Administration. July 1, 2003. p. 14. Archived from the original (PDF) on August 31, 2007. Retrieved 2008-01-08.

[5] "Symrise UV protection products" (PDF). Symrise. Archived from the original (PDF) on 2008-08-21. Retrieved 2008-08-10.

[6] "Cosmetic Products Regulation, Annex VI - Allowed UV Filters". ECHA. Retrieved 2023-08-15.

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v t e Sunscreening agents approved by the US FDA or other agencies
UVA: 400–315 nm UVB: 315–290 nm Chemical agents unless otherwise noted
UVA filters	Avobenzone (Parsol 1789) Bisdisulizole disodium (Neo Heliopan AP) Diethylamino hydroxybenzoyl hexyl benzoate (Uvinul A Plus) Ecamsule (Mexoryl SX) Menthyl anthranilate
UVB filters	Amiloxate 4-Aminobenzoic acid (PABA) Cinoxate Ethylhexyl triazone (Uvinul T 150) Homosalate 4-Methylbenzylidene camphor (Enzacamene) Octyl methoxycinnamate (Octinoxate) Octyl salicylate (Octisalate) Padimate O (Escalol 507) Phenylbenzimidazole sulfonic acid (Ensulizole) Polysilicone-15 (Parsol SLX) Trolamine salicylate
UVA+UVB filters	Bemotrizinol (Tinosorb S) Benzophenones 1–12 Dioxybenzone Drometrizole trisiloxane (Mexoryl XL) Iscotrizinol (Uvasorb HEB) Octocrylene Oxybenzone (Eusolex 4360) Sulisobenzone Hybrid (chemical/physical): Bisoctrizole (Tinosorb M / Eversorb M) Physical: Titanium dioxide Zinc oxide
See also: Photoprotection, Sun protective clothing, Sun tanning, and Sunburn

Names


Preferred IUPAC name Disodium 2,2′-(1,4-phenylene)bis(6-sulfo-1H-1,3-benzimidazole-4-sulfonate)
Identifiers
CAS Number	180898-37-7^Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL2111085^N
ChemSpider	9333274^Y
ECHA InfoCard	100.121.951
PubChem CID	11158166
UNII	Z99XUY03BK^Y
CompTox Dashboard (EPA)	DTXSID001021219
InChI InChI=1S/C20H14N4O12S4.2Na/c25-37(26,27)11-5-13-17(15(7-11)39(31,32)33)23-19(21-13)9-1-2-10(4-3-9)20-22-14-6-12(38(28,29)30)8-16(18(14)24-20)40(34,35)36;;/h1-8H,(H,21,23)(H,22,24)(H,25,26,27)(H,28,29,30)(H,31,32,33)(H,34,35,36);;/q;2+1/p-2^Y Key: GLCJMPWWQKKJQZ-UHFFFAOYSA-L^Y InChI=1/C20H14N4O12S4.2Na/c25-37(26,27)11-5-13-17(15(7-11)39(31,32)33)23-19(21-13)9-1-2-10(4-3-9)20-22-14-6-12(38(28,29)30)8-16(18(14)24-20)40(34,35)36;;/h1-8H,(H,21,23)(H,22,24)(H,25,26,27)(H,28,29,30)(H,31,32,33)(H,34,35,36);;/q;2+1/p-2 Key: GLCJMPWWQKKJQZ-NUQVWONBAQ
SMILES C1=CC(=CC=C1C2=NC3=C(C=C(C=C3N2)S(=O)(=O)O)S(=O)(=O)[O-])C4=NC5=C(C=C(C=C5N4)S(=O)(=O)O)S(=O)(=O)[O-].[Na+].[Na+]
Properties
Chemical formula	C₂₀H₁₂N₄Na₂O₁₂S₄
Molar mass	674.55 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references