CNTRL

CNTRL
Identifiers
AliasesCNTRL, CEP1, CEP110, FAN, bA165P4.1, centriolin
External IDsOMIM: 605496; MGI: 1889576; HomoloGene: 38260; GeneCards: CNTRL; OMA:CNTRL - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001290635
NM_012018
NM_030000
NM_001379274
NM_001379275

RefSeq (protein)

NP_001277564
NP_036148
NP_001366203
NP_001366204

Location (UCSC)Chr 9: 121.07 – 121.18 MbChr 2: 35.11 – 35.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centriolin is a protein that in humans is encoded by the CNTRL gene. It was previously known as CEP110.[5][6]

This gene encodes a centrosomal protein required for the centrosome to function as a microtubule organizing center. The gene product is also associated with centrosome maturation. One version of stem cell myeloproliferative disorder is the result of a reciprocal translocation between chromosomes 8 and 9, with the breakpoint associated with fibroblast growth factor receptor 1 and centriolin.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000119397Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057110Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Guasch G, Mack GJ, Popovici C, Dastugue N, Birnbaum D, Rattner JB, Pebusque MJ (Mar 2000). "FGFR1 is fused to the centrosome-associated protein CEP110 in the 8p12 stem cell myeloproliferative disorder with t(8;9)(p12;q33)". Blood. 95 (5): 1788–96. doi:10.1182/blood.V95.5.1788.005k15_1788_1796. PMID 10688839.
  6. ^ a b "Entrez Gene: CEP110 centrosomal protein 110kDa".
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Further reading

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