Protein-coding gene in the species Homo sapiens
Conserved oligomeric Golgi complex subunit 2 is a protein that in humans is encoded by the COG2 gene .[ 5] [ 6]
Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG2 (Ungar et al., 2002).[ 6]
COG2 has been shown to interact with COG4 [ 7] COG3 .[ 8]
^ a b c GRCh38: Ensembl release 89: ENSG00000135775 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031979 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Podos SD, Reddy P, Ashkenas J, Krieger M (Dec 1994). "LDLC encodes a brefeldin A-sensitive, peripheral Golgi protein required for normal Golgi function" . J Cell Biol . 127 (3): 679–91. doi :10.1083/jcb.127.3.679 . PMC 2120235 PMID 7962052 . ^ a b "Entrez Gene: COG2 component of oligomeric golgi complex 2" .^ Loh, Eva; Hong Wanjin (Jun 2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex" . J. Biol. Chem . 279 (23): 24640–8. doi :10.1074/jbc.M400662200 ISSN 0021-9258 . PMID 15047703 . ^ Loh, Eva; Hong Wanjin (Jun 2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp" . J. Biol. Chem . 277 (24): 21955–61. doi :10.1074/jbc.M202326200 ISSN 0021-9258 . PMID 11929878 . Salesiotis AN, Wang CK, Wang CD, et al. (1995). "Identification of novel genes from stomach cancer cell lines by differential display". Cancer Lett . 91 (1): 47–54. doi :10.1016/0304-3835(95)03717-B . PMID 7750094 . Loh E, Hong W (2002). "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp" . J. Biol. Chem . 277 (24): 21955–61. doi :10.1074/jbc.M202326200 PMID 11929878 . Ungar D, Oka T, Brittle EE, et al. (2002). "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function" . J. Cell Biol . 157 (3): 405–15. doi :10.1083/jcb.200202016 . PMC 2173297 PMID 11980916 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Loh E, Hong W (2004). "The binary interacting network of the conserved oligomeric Golgi tethering complex" . J. Biol. Chem . 279 (23): 24640–8. doi :10.1074/jbc.M400662200 PMID 15047703 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Sohda M, Misumi Y, Yoshimura S, et al. (2007). "The interaction of two tethering factors, p115 and COG complex, is required for Golgi integrity" . Traffic . 8 (3): 270–84. doi :10.1111/j.1600-0854.2006.00530.x PMID 17274799 . 
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