COX7C

COX7C
Identifiers
Aliases	COX7C, cytochrome c oxidase subunit 7C
External IDs	OMIM: 603774; MGI: 103226; HomoloGene: 135674; GeneCards: COX7C; OMA:COX7C - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	86,620,962 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	86,195,023 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; right auricle; ; left ventricle; ; apex of heart; ; muscle of thigh; ; human kidney; ; prefrontal cortex; ; ganglionic eminence; ; biceps brachii; ; mucosa of transverse colon;
	Top expressed in
	quadriceps femoris muscle; ; right kidney; ; yolk sac; ; heart; ; proximal tubule; ; stomach; ; muscle tissue; ; neural tube; ; skeletal muscle tissue; ; jejunum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	cytochrome-c oxidase activity;
Cellular component	integral component of membrane; mitochondrial inner membrane; membrane; mitochondrion; mitochondrial respiratory chain complex IV;
Biological process	proton transmembrane transport; generation of precursor metabolites and energy; mitochondrial electron transport, cytochrome c to oxygen;
	Sources:Amigo / QuickGO
Orthologs
	1350
	12867
	ENSG00000127184
	ENSMUSG00000017778
	P15954
	P17665
	NM_001867
	NM_007749
	NP_001858
	NP_031775
	Wikidata
View/Edit Human	View/Edit Mouse

Cytochrome c oxidase subunit 7C, mitochondrial is an enzyme that in humans is encoded by the COX7C gene.^[5]^[6]

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85% amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A pseudogene COX7CP1 has been found on chromosome 13.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127184 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000017778 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hofmann S, Lichtner P, Schuffenhauer S, Gerbitz KD, Meitinger T (Mar 1999). "Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22→q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14→q21 by FISH and radiation hybrid mapping". Cytogenet Cell Genet. 83 (3–4): 226–7. doi:10.1159/000015185. PMID 10072584.
^ ^a ^b "Entrez Gene: COX7C cytochrome c oxidase subunit VIIc".

External links

Human COX7C genome location and COX7C gene details page in the UCSC Genome Browser.

Lenka N, Vijayasarathy C, Mullick J, Avadhani NG (1998). "Structural organization and transcription regulation of nuclear genes encoding the mammalian cytochrome c oxidase complex". Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 61: 309–44. doi:10.1016/S0079-6603(08)60830-2. ISBN 9780125400619. PMID 9752724.
Sirchia R, Luparello C (2007). "Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells". Biol. Chem. 388 (5): 457–65. doi:10.1515/BC.2007.059. PMID 17516841. S2CID 2286919.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Kaminishi H, Hamatake H, Cho T, et al. (1994). "Activation of blood clotting factors by microbial proteinases". FEMS Microbiol. Lett. 121 (3): 327–32. doi:10.1111/j.1574-6968.1994.tb07121.x. PMID 7926688.
Koga Y, Fabrizi GM, Mita S, et al. (1990). "Sequence of a cDNA specifying subunit VIIc of human cytochrome c oxidase". Nucleic Acids Res. 18 (3): 684. doi:10.1093/nar/18.3.684. PMC 333506. PMID 2155413.
Van Kuilenburg AB, Van Beeumen JJ, Van der Meer NM, Muijsers AO (1992). "Subunits VIIa,b,c of human cytochrome c oxidase. Identification of both 'heart-type' and 'liver-type' isoforms of subunit VIIa in human heart". Eur. J. Biochem. 203 (1–2): 193–9. doi:10.1111/j.1432-1033.1992.tb19847.x. PMID 1309697.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000127184 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000017778 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10072584-5] Hofmann S, Lichtner P, Schuffenhauer S, Gerbitz KD, Meitinger T (Mar 1999). "Assignment of the human genes coding for cytochrome c oxidase subunits Va (COX5A), VIc (COX6C) and VIIc (COX7C) to chromosome bands 15q25, 8q22→q23 and 5q14 and of three pseudogenes (COX5AP1, COX6CP1, COX7CP1) to 14q22, 16p12 and 13q14→q21 by FISH and radiation hybrid mapping". Cytogenet Cell Genet. 83 (3–4): 226–7. doi:10.1159/000015185. PMID 10072584.

[entrez-6] "Entrez Gene: COX7C cytochrome c oxidase subunit VIIc".

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COX7C

References

External links

Further reading