Carbonic anhydrase 7

CA7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3MDZ, 3ML5
Identifiers
Aliases	CA7, CAVII, carbonic anhydrase 7, CA-VII
External IDs	OMIM: 114770; MGI: 103100; HomoloGene: 55875; GeneCards: CA7; OMA:CA7 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	66,854,153 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	105,276,975 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; rectum; ; mucosa of sigmoid colon; ; testicle; ; Brodmann area 10; ; right frontal lobe; ; Brodmann area 9; ; putamen; ; caudate nucleus; ; cingulate gyrus;
	Top expressed in
	yolk sac; ; Paneth cell; ; trigeminal ganglion; ; facial motor nucleus; ; substantia nigra; ; cerebellar vermis; ; lobe of cerebellum; ; visual cortex; ; Region I of hippocampus proper; ; primary visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	carbonate dehydratase activity; zinc ion binding; metal ion binding; lyase activity; carbonic anhydrase;
Cellular component	cytoplasm; cytosol;
Biological process	bicarbonate transport; positive regulation of cellular pH reduction; positive regulation of synaptic transmission, GABAergic; regulation of chloride transport;
	Sources:Amigo / QuickGO
Orthologs
	766
	12354
	ENSG00000168748
	ENSMUSG00000031883
	P43166
	Q9ERQ8
	NM_001014435; NM_005182; NM_001365337
	NM_001301164; NM_001301165; NM_053070
	NP_001014435; NP_005173; NP_001352266
	NP_001288093; NP_001288094; NP_444300
	Wikidata
View/Edit Human	View/Edit Mouse

Carbonic anhydrase 7 (CA7) is an enzyme that in humans is encoded by the CA7 gene.^[5]^[6]

Function

Carbonic anhydrases are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. The cytosolic protein encoded by this gene is predominantly expressed in the salivary glands. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168748 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031883 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Montgomery JC, Venta PJ, Eddy RL, Fukushima YS, Shows TB, Tashian RE (Dec 1991). "Characterization of the human gene for a newly discovered carbonic anhydrase, CA VII, and its localization to chromosome 16" (PDF). Genomics. 11 (4): 835–48. doi:10.1016/0888-7543(91)90006-Z. hdl:2027.42/29017. PMID 1783392.
^ ^a ^b "Entrez Gene: CA7 carbonic anhydrase VII".

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Carbonic anhydrase 7

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168748 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031883 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1783392-5] Montgomery JC, Venta PJ, Eddy RL, Fukushima YS, Shows TB, Tashian RE (Dec 1991). "Characterization of the human gene for a newly discovered carbonic anhydrase, CA VII, and its localization to chromosome 16" (PDF). Genomics. 11 (4): 835–48. doi:10.1016/0888-7543(91)90006-Z. hdl:2027.42/29017. PMID 1783392.

[entrez-6] "Entrez Gene: CA7 carbonic anhydrase VII".

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Carbonic anhydrase 7

Function

References

Further reading

External links