DPP8

DPP8
Identifiers
AliasesDPP8, DP8, DPRP1, MSTP141, MST097, MSTP097, MSTP135, DPRP-1, dipeptidyl peptidase 8
External IDsOMIM: 606819; MGI: 1921638; HomoloGene: 57098; GeneCards: DPP8; OMA:DPP8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_028906
NM_001401136

RefSeq (protein)

NP_083182
NP_001388065

Location (UCSC)Chr 15: 65.44 – 65.52 MbChr 9: 64.94 – 64.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Dipeptidyl peptidase 8 is an enzyme that in humans is encoded by the DPP8 gene.[5][6]

This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase-4 in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described.[6] A relatively specific inhibitor of DPP8 and DPP9, Val-boroPro [7]-,[8] leads to increased activation of the inflammasome though both NLRBP1 and CARD8 and can trigger pyroptosis.[9]

References

[edit]
Notes
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000074603Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032393Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Abbott CA, Yu DM, Woollatt E, Sutherland GR, McCaughan GW, Gorrell MD (Nov 2000). "Cloning, expression and chromosomal localization of a novel human dipeptidyl peptidase (DPP) IV homolog, DPP8". Eur J Biochem. 267 (20): 6140–50. doi:10.1046/j.1432-1327.2000.01617.x. PMID 11012666.
  6. ^ a b "Entrez Gene: DPP8 dipeptidyl-peptidase 8".
  7. ^ "PubChem:Val-boroPro".
  8. ^ Okondo MC, Rao SD, Taabazuing CY, Chui AJ, Poplawski SE, Johnson DC, Bachovchin DA (March 2018). "Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome". Cell Chemical Biology. 25 (3): 262–267.e5. doi:10.1016/j.chembiol.2017.12.013. PMC 5856610. PMID 29396289.
  9. ^ Johnson DC, Taabazuing CY, Okondo MC, Chui AJ, Rao SD, Brown FC, Reed C, Peguero E, de Stanchina E, Kentsis A, Bachovchin DA (August 2018). "DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia". Nature Medicine. 24 (8): 1151–1156. doi:10.1038/s41591-018-0082-y. PMC 6082709. PMID 29967349.
Further reading