Dennie–Marfan syndrome

Dennie–Marfan syndrome
Dennie–Marfan syndrome
Specialty	Neurology

Dennie–Marfan syndrome is a syndrome in which there is association of spastic paraplegia of the lower limbs and mental retardation in children with congenital syphilis.^[1] Both sexes are affected, and the onset of the disease can be acute or insidious, with slow progression from weakness to quadriplegia. Epilepsy, cataract, and nystagmus may also be found.^{[citation needed]}

The syndrome was described by Charles Clayton Dennie in 1929,^[2] and Antoine Marfan in 1936.^[3]

References

^ M.D, Mark E. Williams (2009). Geriatric Physical Diagnosis: A Guide to Observation and Assessment. McFarland. p. 56. ISBN 9780786451609.
^ Dennie CC. Partial paralysis of the lower extremities in children, accompanied by backward mental development. Am J Syphilis 1929; 13: 157–163
^ Marfan AB. Paraplégie spasmodique avec troubles cérébraux d’origine hérédo-syphilitique chez les grands enfants. Revue Franc Pédiat 1936; 12: 1–16

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v t e Signs and symptoms relating to infectious diseases
Bacterial disease	syphilis Hutchinson's teeth Hutchinson's triad Westphal's sign Clutton's joints Dennie–Marfan syndrome
Viral disease	measles Koplik's spots
Parasitic disease	African trypanosomiasis Winterbottom's sign
General	Meningism Fever Liebermeister's rule Faget sign