EIF4EBP3

EIF4EBP3
Identifiers
Aliases	EIF4EBP3, 4E-BP3, 4EBP3, eukaryotic translation initiation factor 4E binding protein 3
External IDs	OMIM: 603483; MGI: 1270847; HomoloGene: 37841; GeneCards: EIF4EBP3; OMA:EIF4EBP3 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	140,549,576 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	36,798,970 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; gastrocnemius muscle; ; olfactory zone of nasal mucosa; ; muscle of thigh; ; right adrenal cortex; ; body of stomach; ; left adrenal cortex; ; minor salivary glands; ; fundus; ; skin of leg;
	Top expressed in
	ileum; ; renal cortex; ; proximal tubule; ; bone marrow; ; right kidney; ; liver; ; colon; ; jejunum; ; duodenum; ; human kidney;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; eukaryotic initiation factor 4E binding; translation repressor activity;
Cellular component	cytoplasm; eukaryotic translation initiation factor 4F complex; membrane;
Biological process	negative regulation of translation; regulation of translation; negative regulation of translational initiation;
	Sources:Amigo / QuickGO
Orthologs
	8637
	108112
	ENSG00000243056
	ENSMUSG00000090264
	O60516
	Q80VV3
	NM_003732
	NM_201256
	NP_003723
	NP_957708
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 4E-binding protein 3 is a protein that in humans is encoded by the EIF4EBP3 gene.^[5]^[6]

Function

This gene encodes a member of the EIF4EBP family which derives its name from proteins that bind to eukaryotic initiation factor 4E and that prevent its assembly into EIF4F. Co-transcription of this gene and the neighboring upstream gene (MASK) generates a transcript (MASK-BP3) which encodes a fusion protein composed of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments.^[6]

Interactions

EIF4EBP3 has been shown to interact with EIF4E.^[5]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000243056 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000090264 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Poulin F, Gingras AC, Olsen H, Chevalier S, Sonenberg N (Jul 1998). "4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family". J. Biol. Chem. 273 (22): 14002–7. doi:10.1074/jbc.273.22.14002. PMID 9593750.
^ ^a ^b "Entrez Gene: EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3".
^ Kleijn M, Scheper GC, Wilson ML, Tee AR, Proud CG (Dec 2002). "Localisation and regulation of the eIF4E-binding protein 4E-BP3". FEBS Lett. 532 (3): 319–23. doi:10.1016/S0014-5793(02)03694-3. PMID 12482586. S2CID 24527449.

Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Joshi B, Cameron A, Jagus R (2004). "Characterization of mammalian eIF4E-family members". Eur. J. Biochem. 271 (11): 2189–203. doi:10.1111/j.1432-1033.2004.04149.x. PMID 15153109.
Poulin F, Brueschke A, Sonenberg N (2003). "Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK". J. Biol. Chem. 278 (52): 52290–7. doi:10.1074/jbc.M310761200. PMID 14557257.
Ferguson G, Mothe-Satney I, Lawrence JC (2003). "Ser-64 and Ser-111 in PHAS-I are dispensable for insulin-stimulated dissociation from eIF4E". J. Biol. Chem. 278 (48): 47459–65. doi:10.1074/jbc.M307949200. PMID 14507920.
Kleijn M, Scheper GC, Wilson ML, Tee AR, Proud CG (2002). "Localisation and regulation of the eIF4E-binding protein 4E-BP3". FEBS Lett. 532 (3): 319–23. doi:10.1016/S0014-5793(02)03694-3. PMID 12482586. S2CID 24527449.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000243056 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000090264 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9593750-5] Poulin F, Gingras AC, Olsen H, Chevalier S, Sonenberg N (Jul 1998). "4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family". J. Biol. Chem. 273 (22): 14002–7. doi:10.1074/jbc.273.22.14002. PMID 9593750.

[entrez-6] "Entrez Gene: EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3".

[pmid12482586-7] Kleijn M, Scheper GC, Wilson ML, Tee AR, Proud CG (Dec 2002). "Localisation and regulation of the eIF4E-binding protein 4E-BP3". FEBS Lett. 532 (3): 319–23. doi:10.1016/S0014-5793(02)03694-3. PMID 12482586. S2CID 24527449.

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EIF4EBP3

Function

Interactions

References

Further reading