Elizabeth Jonas (neurologist)

Elizabeth Jonas
Elizabeth Jonas
Born	Elizabeth Ann Jonas
Education	Yale University (1982); NYU School of Medicine (1986);
Spouse	Thomas Eisen
	Scientific career
Fields	Neuroscience
Institutions	Yale School of Medicine; Marine Biological Laboratory;

Elizabeth Ann Jonas is an American physician and neuroscientist at the Yale School of Medicine where she is Professor of endocrinology and neuroscience. Her seminal work includes the first in vivo electrical recordings of mitochrondrial membrane potentials and influential research on metabolic pathways of neuronal death.

Career and research

An alumna of the Fieldston School, Jonas graduated from Yale University in 1982 and received her medical degree from New York University School of Medicine in 1986.^[1]^[2] As an undergraduate, she studied under the neuroscientist Rodolfo Llinás at the Marine Biological Laboratory in Woods Hole.^[3] She returned to the laborartory as a post-doctoral fellow of Len Kaczmarek where her work on the squid giant synapse constituted the first ever direct electrical recordings of mitochondrial membrane potentials in vivo.^[4] Her work since has built upon this technique to describe the mitochondrial permeability transition pore and its influence on neurological disease.^[5]^[6]^[7]

Jonas is appointed as Professor of Endocrinology within the Departments of Internal Medicine and Neuroscience at Yale School of Medicine. She also serves as the school's co-chair of the Committee on the Status of Women in Medicine and has been outspoken in her support for gender equality in medicine.^[8]^[9]

Awards and honors

National Institute of Neurological Disorders and Stroke Javits Neuroscience Investigator Award (2013, 2021)^[10]
Association of American Physicians (2022)^[11]

References

^ "Professor Elizabeth Jonas - The Mitochondrion: The Powerhouse Behind Neurotransmission". scientia.global. 2017-02-21. Retrieved 2022-08-24.
^ "Dr. Elizabeth A. Jonas Plans to Wed in March". The New York Times. 1987-11-22. ISSN 0362-4331. Retrieved 2022-09-30.
^ "Legends of Squid Research at the MBL: Chasing Down Why Neurons Live or Die". Marine Biological Laboratory. Retrieved 2022-08-24.
^ Jonas, Elizabeth A.; Buchanan, JoAnn; Kaczmarek, Leonard K. (1999-11-12). "Prolonged Activation of Mitochondrial Conductances During Synaptic Transmission". Science. 286 (5443): 1347–1350. doi:10.1126/science.286.5443.1347. ISSN 0036-8075. PMID 10558987.
^ Alavian, Kambiz N.; Beutner, Gisela; Lazrove, Emma; Sacchetti, Silvio; Park, Han-A; Licznerski, Pawel; Li, Hongmei; Nabili, Panah; Hockensmith, Kathryn; Graham, Morven; Porter, George A.; Jonas, Elizabeth A. (2014-07-22). "An uncoupling channel within the c-subunit ring of the F 1 F O ATP synthase is the mitochondrial permeability transition pore". Proceedings of the National Academy of Sciences. 111 (29): 10580–10585. Bibcode:2014PNAS..11110580A. doi:10.1073/pnas.1401591111. ISSN 0027-8424. PMC 4115574. PMID 24979777.
^ Licznerski, Pawel; Park, Han-A.; Rolyan, Harshvardhan; Chen, Rongmin; Mnatsakanyan, Nelli; Miranda, Paige; Graham, Morven; Wu, Jing; Cruz-Reyes, Nicole; Mehta, Nikita; Sohail, Sana; Salcedo, Jorge; Song, Erin; Effman, Charles; Effman, Samuel (2020-09-03). "ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome". Cell. 182 (5): 1170–1185.e9. doi:10.1016/j.cell.2020.07.008. ISSN 0092-8674. PMC 7484101. PMID 32795412.
^ Mnatsakanyan, Nelli; Llaguno, Marc C.; Yang, Youshan; Yan, Yangyang; Weber, Joachim; Sigworth, Fred J.; Jonas, Elizabeth A. (2019-12-20). "A mitochondrial megachannel resides in monomeric F1FO ATP synthase". Nature Communications. 10 (1): 5823. Bibcode:2019NatCo..10.5823M. doi:10.1038/s41467-019-13766-2. ISSN 2041-1723. PMC 6925261. PMID 31862883.
^ "Yale missteps allowed professor to prey on students for decades, report finds". Washington Post. ISSN 0190-8286. Retrieved 2022-08-24.
^ Horowitch, Rose; pm, Beatriz Horta 11:53 (2020-10-08). "Yale settles with Department of Labor after underpaying female cardiologists". Yale Daily News. Retrieved 2022-08-24.{{cite web}}: CS1 maint: numeric names: authors list (link)
^ "Elizabeth Jonas | National Institute of Neurological Disorders and Stroke". www.ninds.nih.gov. April 2013. Retrieved 2022-08-24.
^ Parry, Julie. "Gross, Jonas, O'Connor Elected to AAP". medicine.yale.edu. Retrieved 2022-08-24.

[1] "Professor Elizabeth Jonas - The Mitochondrion: The Powerhouse Behind Neurotransmission". scientia.global. 2017-02-21. Retrieved 2022-08-24.

[2] "Dr. Elizabeth A. Jonas Plans to Wed in March". The New York Times. 1987-11-22. ISSN 0362-4331. Retrieved 2022-09-30.

[3] "Legends of Squid Research at the MBL: Chasing Down Why Neurons Live or Die". Marine Biological Laboratory. Retrieved 2022-08-24.

[4] Jonas, Elizabeth A.; Buchanan, JoAnn; Kaczmarek, Leonard K. (1999-11-12). "Prolonged Activation of Mitochondrial Conductances During Synaptic Transmission". Science. 286 (5443): 1347–1350. doi:10.1126/science.286.5443.1347. ISSN 0036-8075. PMID 10558987.

[5] Alavian, Kambiz N.; Beutner, Gisela; Lazrove, Emma; Sacchetti, Silvio; Park, Han-A; Licznerski, Pawel; Li, Hongmei; Nabili, Panah; Hockensmith, Kathryn; Graham, Morven; Porter, George A.; Jonas, Elizabeth A. (2014-07-22). "An uncoupling channel within the c-subunit ring of the F 1 F O ATP synthase is the mitochondrial permeability transition pore". Proceedings of the National Academy of Sciences. 111 (29): 10580–10585. Bibcode:2014PNAS..11110580A. doi:10.1073/pnas.1401591111. ISSN 0027-8424. PMC 4115574. PMID 24979777.

[6] Licznerski, Pawel; Park, Han-A.; Rolyan, Harshvardhan; Chen, Rongmin; Mnatsakanyan, Nelli; Miranda, Paige; Graham, Morven; Wu, Jing; Cruz-Reyes, Nicole; Mehta, Nikita; Sohail, Sana; Salcedo, Jorge; Song, Erin; Effman, Charles; Effman, Samuel (2020-09-03). "ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome". Cell. 182 (5): 1170–1185.e9. doi:10.1016/j.cell.2020.07.008. ISSN 0092-8674. PMC 7484101. PMID 32795412.

[7] Mnatsakanyan, Nelli; Llaguno, Marc C.; Yang, Youshan; Yan, Yangyang; Weber, Joachim; Sigworth, Fred J.; Jonas, Elizabeth A. (2019-12-20). "A mitochondrial megachannel resides in monomeric F1FO ATP synthase". Nature Communications. 10 (1): 5823. Bibcode:2019NatCo..10.5823M. doi:10.1038/s41467-019-13766-2. ISSN 2041-1723. PMC 6925261. PMID 31862883.

[8] "Yale missteps allowed professor to prey on students for decades, report finds". Washington Post. ISSN 0190-8286. Retrieved 2022-08-24.

[9] Horowitch, Rose; pm, Beatriz Horta 11:53 (2020-10-08). "Yale settles with Department of Labor after underpaying female cardiologists". Yale Daily News. Retrieved 2022-08-24.{{cite web}}: CS1 maint: numeric names: authors list (link)

[10] "Elizabeth Jonas | National Institute of Neurological Disorders and Stroke". www.ninds.nih.gov. April 2013. Retrieved 2022-08-24.

[11] Parry, Julie. "Gross, Jonas, O'Connor Elected to AAP". medicine.yale.edu. Retrieved 2022-08-24.

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