Etidocaine
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Clinical data | |
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Trade names | Duranest |
AHFS/Drugs.com | Micromedex Detailed Consumer Information |
MedlinePlus | a603026 |
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Routes of administration | Parenteral |
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Pharmacokinetic data | |
Bioavailability | n/a |
Metabolism | Hepatic |
Elimination half-life | 2.5 hours |
Excretion | Renal |
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ECHA InfoCard | 100.048.296 |
Chemical and physical data | |
Formula | C17H28N2O |
Molar mass | 276.424 g·mol−1 |
3D model (JSmol) | |
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Etidocaine, marketed under the trade name Duranest, is an amide-type local anesthetic given by injection during surgical procedures and labor and delivery. Etidocaine has a long duration of activity, and the main disadvantage of using during dentistry is increased bleeding during surgery.[1]
Synthesis
[edit]![](http://upload.wikimedia.org/wikipedia/commons/thumb/a/a3/Etidocaine_synthesis.svg/500px-Etidocaine_synthesis.svg.png)
The amide reaction between 2,6-xylidine (1) and 2-bromobutyryl chloride [22118-12-3] (2) gives 2-Bromo-N-(2,6-Dimethylphenyl)Butanamide [53984-81-9] (3). Alkylation with N-Ethylpropylamine [20193-20-8] (4) gives Etidocaine (5).
References
[edit]- ^ Sisk AL (1992). "Long-acting local anesthetics in dentistry". Anesthesia Progress. 39 (3): 53–60. PMC 2148750. PMID 1308373.
- ^ DE2162744 idem H Adams, G Kronberg, B Takman, U.S. patent 3,812,147 (1974 to Astra Pharma Prod).
- ^ Org. Synth. 1950, 30, 62. DOI: 10.15227/orgsyn.030.0062
External links
[edit]- Duranest (RxList)