Fluticasone
![]() | |
Clinical data | |
---|---|
Other names | 6α,9α-Difluoro-11β,17α-dihydroxy-16α-methyl-21-thia-21-fluoromethylpregna-1,4-dien-3,20-dione; S-(Fluoromethyl)-6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioate |
Routes of administration | Intranasal, inhaled, topical |
ATC code | |
Legal status | |
Legal status |
|
Pharmacokinetic data | |
Bioavailability | 0.51% (Intranasal) |
Protein binding | 91.0% |
Metabolism | Intranasal Liver (CYP3A4-mediated) |
Elimination half-life | 10 hours |
Excretion | Kidney |
Identifiers | |
| |
CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
DrugBank | |
ChemSpider | |
UNII | |
KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
Chemical and physical data | |
Formula | C22H27F3O4S |
Molar mass | 444.51 g·mol−1 |
3D model (JSmol) | |
| |
| |
![]() ![]() |
Fluticasone is a manufactured glucocorticoid used to treat nasal symptoms.[1][2][3][4][5] Both the esters, fluticasone propionate (a brand name for which is Flovent) and fluticasone furoate, are also used as topical anti-inflammatories and inhaled corticosteroids, and are used much more commonly in comparison.[3][2][4][6]
It is on the World Health Organization's List of Essential Medicines.[7] In 2021, it was the 23rd most commonly prescribed medication in the United States, with more than 25 million prescriptions,[8][9] although it is also sold over the counter.[10]
See also
[edit]References
[edit]- ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 574–. ISBN 978-1-4757-2085-3.
- ^ a b Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 1337–. ISBN 978-3-88763-075-1.
- ^ a b Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 124–. ISBN 978-94-011-4439-1.
- ^ a b "Fluticasone - FDA prescribing information, side effects and uses".
- ^ Briggs GG, Freeman RK, Yaffe SJ (2012). Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Lippincott Williams & Wilkins. p. 600. ISBN 978-1451153590.
- ^ Spratto GR, Woods AL (2012). Delmar Nurse's Drug Handbook 2012. Cengage Learning. p. 748. ISBN 978-1111310653.
- ^ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
- ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
- ^ "Fluticasone - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
- ^ "Fluticasone Nasal Spray". Retrieved 21 October 2022.