Formyltetrahydrofolate deformylase
formyltetrahydrofolate deformylase | |||||||||
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Identifiers | |||||||||
EC no. | 3.5.1.10 | ||||||||
CAS no. | 9025-08-5 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a formyltetrahydrofolate deformylase (EC 3.5.1.10) is an enzyme that catalyzes the chemical reaction
- 10-formyltetrahydrofolate + H2O formate + tetrahydrofolate
Thus, the two substrates of this enzyme are 10-formyltetrahydrofolate and H2O, whereas its two products are formate and tetrahydrofolate.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is 10-formyltetrahydrofolate amidohydrolase. This enzyme participates in glyoxylate and dicarboxylate metabolism and one carbon pool by folate.
References
[edit]- Huennekens FM (1957). "Enzymatic deacylation of N10-formyltetrahydrofolic acid". Fed. Proc. 16: 199.