Protein-coding gene in the species Homo sapiens
Gem-associated protein 4 is a protein that in humans is encoded by the GEMIN4 gene .[ 5] [ 6]
The product of this gene is part of the SMN protein complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems) . The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[ 6]
GEMIN4 has been shown to interact with:
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