Guanylate cyclase 2C , also known as guanylyl cyclase C (GC-C ), intestinal guanylate cyclase , guanylate cyclase-C receptor , or the heat-stable enterotoxin receptor (hSTAR ) is an enzyme that in humans is encoded by the GUCY2C gene .[ 5] [ 6]
Guanylyl cyclase is an enzyme found in the luminal aspect of intestinal epithelium and dopamine neurons in the brain .[ 7] extracellular ligand -binding domain, a single transmembrane region , a region with sequence similar to that of protein kinases , and a C-terminal guanylate cyclase domain. Tyrosine kinase activity mediates the GC-C signaling pathway within the cell .
GC-C is a key receptor for heat-stable enterotoxins that are responsible for acute secretory diarrhea .[ 8] pathogens such as Escherichia coli Knockout mice deficient in the GC-C gene do not show secretory diarrhea on infection with E. coli , though they do with cholera toxin. This demonstrates the specificity of the GC-C receptor.
Guanylate cyclase 2C is the target of linaclotide and plecanatide , oligopeptide agonists used for the treatment of chronic constipation .
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