HCP5

The gene known as HCP5 (HLA Complex P5) is a human endogenous retrovirus, meaning that it is a fossil of an ancient virus that at one time infected people, but has now become an integral part of the human genome.^[1]

One variation of HCP5 appears to provide some delay or resistance to the development of AIDS when a person is infected with HIV. This variation of HCP5 frequently occurs in conjunction with a particular version of an immune system gene called HLA-B.^[1]

HCP5 has been reported to become upregulated after human papillomavirus infection and may promote the development of cervical cancer.^[2]^[3]

Notes and references

^ ^a ^b AIDS Abated, B. Vastag, Science News Vol.172 No.3, 21 July 2007
^ Ramachandran D, Schürmann P, Mao Q, Wang Y, Bretschneider LM, Speith LM, Hülse F, Enßen J, Bousset K, Jentschke M, Böhmer G, Strauß HG, Hirchenhain C, Schmidmayr M, Tarbiat J, Runnebaum I, Dürst M, Hein A, Koch M, Ruebner M, Ekici A, Beckmann MW, Fasching PA, Luyten A, Petry KU, Hillemanns P, Dörk T (2020). "Association of genomic variants at the Human Leukocyte Antigen locus with cervical cancer risk, HPV status, and gene expression levels". Int J Cancer. 147 (9): 2458–2468. doi:10.1002/ijc.33171. PMID 32580243.
^ Yu Y, Shen HM, Fang DM, Meng QJ, Xin YH (2018). "LncRNA HCP5 promotes the development of cervical cancer by regulating MACC1 via suppression of microRNA-15a". Eur Rev Med Pharmacol Sci. 22 (15). doi:10.26355/eurrev_201808_15616. PMID 30070314.

[SN-1] AIDS Abated, B. Vastag, Science News Vol.172 No.3, 21 July 2007

[2] Ramachandran D, Schürmann P, Mao Q, Wang Y, Bretschneider LM, Speith LM, Hülse F, Enßen J, Bousset K, Jentschke M, Böhmer G, Strauß HG, Hirchenhain C, Schmidmayr M, Tarbiat J, Runnebaum I, Dürst M, Hein A, Koch M, Ruebner M, Ekici A, Beckmann MW, Fasching PA, Luyten A, Petry KU, Hillemanns P, Dörk T (2020). "Association of genomic variants at the Human Leukocyte Antigen locus with cervical cancer risk, HPV status, and gene expression levels". Int J Cancer. 147 (9): 2458–2468. doi:10.1002/ijc.33171. PMID 32580243.

[3] Yu Y, Shen HM, Fang DM, Meng QJ, Xin YH (2018). "LncRNA HCP5 promotes the development of cervical cancer by regulating MACC1 via suppression of microRNA-15a". Eur Rev Med Pharmacol Sci. 22 (15). doi:10.26355/eurrev_201808_15616. PMID 30070314.

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