Intergenic lcrF RNA thermometer

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LcrF intergenic thermometer
Predicted secondary structure and sequence conservation of LcrF intergenic thermometer
Identifiers
Rfam	RF02704
Other data
Domain(s)	Bacteria
GO	GO:0045975,GO:0009266
SO	SO:0005836
PDB structures	PDBe

RNA thermometers regulate gene expression in response to temperature allowing pathogens like Yersinia to switch on silent genes after entering the host organism. Usually, RNA thermometers are located in the 5'UTR, but an intergenic RNA thermometer was found in Yersinia pseudotuberculosis. The LcrF RNA thermometer together with the thermo-labile YmoA protein activates synthesis of the most crucial virulence activator LcrF (VirF). The RNA thermosensor sequence is 100% identical in all human pathogenic Yersinia species.^[1][2]

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