Isopropyl nitrite

Isopropyl nitrite
Clinical data
Other namesIsopropyl alcohol nitrite; nitrous acid, isopropyl ester; 1-methylethyl nitrite; 2-propyl nitrite
ATC code
  • None
Legal status
Legal status
Identifiers
  • 2-propyl nitrite
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
ECHA InfoCard100.007.982 Edit this at Wikidata
Chemical and physical data
FormulaC3H7NO2
Molar mass89.094 g·mol−1
3D model (JSmol)
Density0.8684 g/cm3
Boiling point40 °C (104 °F)
  • O=NOC(C)C
  • InChI=1S/C3H7NO2/c1-3(2)6-4-5/h3H,1-2H3 checkY
  • Key:SKRDXYBATCVEMS-UHFFFAOYSA-N checkY
  (verify)

The chemical compound isopropyl nitrite (or 2-propyl nitrite) is an alkyl nitrite made from isopropanol. It is a clear pale yellow oil that is insoluble in water.[3]

Isopropyl nitrite in a glass bottle

Applications

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Isopropyl nitrite is one of the compounds used as poppers, an inhalant drug that induces a brief euphoria.

Safety

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Isopropyl nitrite has been associated with eye maculopathy, visual impairment with central scotomata, bilateral foveal yellow spots, and inner segment/outer segment (IS/OS) junction disruption,[4] which may be reversible.[5]

References

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  1. ^ Therapeutic Goods (Poisons Standard—October 2024) Instrument 2024 (Cth)
  2. ^ Anvisa (2024-05-28). "RDC Nº 877 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 877 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União. Archived from the original on 2024-09-25. Retrieved 2024-09-25.
  3. ^ Lide DR, ed. (2004). Handbook of Chemistry and Physics (85th ed.). CRC Press. ISBN 978-0-8493-0485-9.
  4. ^ Davies AJ, Kelly SP, Naylor SG, Bhatt PR, Mathews JP, Sahni J, et al. (November 2012). "Adverse ophthalmic reaction in poppers users: case series of 'poppers maculopathy'". Eye. 26 (11): 1479–1486. doi:10.1038/eye.2012.191. PMC 3496104. PMID 23079752.
  5. ^ Vignal-Clermont C, Audo I, Sahel JA, Paques M (October 2010). "Poppers-associated retinal toxicity". The New England Journal of Medicine. 363 (16): 1583–5. doi:10.1056/NEJMc1005118. PMID 20942681.