John M. Sedivy

John Michael Sedivy is the Hermon C. Bumpus Professor of Biology and a professor of Medical Science at Brown University. He is listed as a F1000 Prime faculty member and on Who's Who in Gerontology. He has published over 130 original articles.^[1]

He wrote the first book on gene targeting in 1992.^[2] In 2006, he published the first comprehensive in vivo quantification of cellular senescence in aging primates. That year, his lab also discovered how (through the Polycomb pathway) c-Myc contributes to the regulation of chromatin states. His research has found that mice missing one copy of the Myc transcription factor live longer than wild-type mice.^[3]

He is co-Editor-in-Chief of the journal Aging Cell, and is chair of the 2015 Gordon Research Conference on the Biology of Aging.

• Sedivy, J. M., & Joyner, A. L. (1992). Gene targeting. WH Freeman and company. ISBN 9780195099683

• Sedivy, J. M., & Sharp, P. A. (1989). Positive genetic selection for gene disruption in mammalian cells by homologous recombination. Proceedings of the National Academy of Sciences, 86(1), 227–231.

• 1974 Ontario Scholar
• 1981 Ryan Foundation Fellow
• 1989 March of Dimes Basil O'Connor Starter Scholar
• 1990 Presidential Young Investigator
• 1991 Andrew Mellon Award
• 2006 Hermon C. Bumpus Endowed Chair in Biology, Brown University
• 2007 Senior Research Scholar in Aging, Ellison Medical Foundation
• 2009 NIH MERIT Award, National Institute on Aging
• 2011 Glenn Award for Research in Biological Mechanisms of Aging
• 2015 Chair, Gordon Research Conference on the Biology of Aging

• John M Sedivy's research works Brown University