Jose Cruz
José Cruz (born 1947), is a former Puerto Rican baseball player
Jose Cruz may also refer to:
- José Cruz (pitcher), baseball player
- Jose B. Cruz Jr., Filipino mathematician
- José de la Cruz (1746–1829), Filipino writer
- José Cruz (Honduran footballer) (born 1949), Honduran footballer
- Camarón de la Isla (1950–1992), stage name of José Monje Cruz
- José Luis Cruz Cruz (born 1959), Puerto Rican politician and mayor of Trujillo Alto
- José Cruz Jr. (born 1974), baseball player
- José E. Cruz (born 1984), baseball player with the Spanish national team
- José Cruz (Spanish footballer) (born 1988), Spanish footballer
- José da Cruz Cardinal Policarpo (1936–2014)
- Jose Cruz (Oklahoma politician), member of the Oklahoma House of Representatives