Kallistatin

SERPINA4
Identifiers
AliasesSERPINA4, KAL, KLST, KST, PI-4, PI4, kallistatin, serpin family A member 4
External IDsOMIM: 147935; HomoloGene: 48412; GeneCards: SERPINA4; OMA:SERPINA4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006215
NM_001289032
NM_001289033

n/a

RefSeq (protein)

NP_001275961
NP_001275962
NP_006206

n/a

Location (UCSC)Chr 14: 94.56 – 94.57 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Kallistatin is a protein that in humans is encoded by the SERPINA4 gene.[3][4]

Kallistatin consists of three folded ß segments and eight helical structures and contains two functional domains, an active site and a heparin-binding site.

Kallistatin signals through several receptors, including integrin ß3, lipoprotein receptor-related protein 6 ( LRP6 ), nucleolin, and Krüppel-like factor 4 ( KLF4 ).[5][6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100665Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Chai KX, Chen LM, Chao J, Chao L (Dec 1993). "Kallistatin: a novel human serine proteinase inhibitor. Molecular cloning, tissue distribution, and expression in Escherichia coli". J Biol Chem. 268 (32): 24498–505. doi:10.1016/S0021-9258(20)80553-5. PMID 8227002.
  4. ^ "Entrez Gene: SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4".
  5. ^ Wang G, Zou J, Yu X, Yin S, Tang C (June 2020). "The antiatherogenic function of kallistatin and its potential mechanism". Acta Biochim Biophys Sin (Shanghai). 52 (6): 583–589. doi:10.1093/abbs/gmaa035. PMID 32393963.
  6. ^ "ABBS : The antiatherogenic function of kallistatin and its potential mechanism".

Further reading

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