On 14 May 1749 Sheptycki was ordained by bishop of Luck Theodosius Rudnicki-Lubieniecki with help of Theodosius Godebski and Adam Oranski as a bishop of Lwow.
On 20 December 1762 he was confirmed as the Coadjutor Metropolitan bishop of Kiev, Galicia, and all Ruthenia. On 1 February 1778 he succeeded Metropolitan Philip.
He consecrated following bishops Gedeon Horbacki, and Athanasius Szeptycki. He died on 24 May 1779
^The title is also known as the Metropolis of Kiev, Halych and all Rus' or Metropolis of Kyiv, Halychyna, and All-Rus'. The name "Galicia" is a Latinized form of Halych, one of several regional principalities of the medieval state of Kievan Rus'.