| # | Date | Film | Gross (USD) | Openings in the top ten |
| 1 | January 2, 2011 | Tron: Legacy | $2,084,555 | Little Fockers (#2), The Next Three Days (#7) |
| 2 | January 9, 2011 | $1,546,548 | Unstoppable (#4), Hereafter (#6) |
| 3 | January 16, 2011 | The Tourist | $1,534,545 | Splice (#8) |
| 4 | January 23, 2011 | The Green Hornet | $2,525,698 | Love & Other Drugs (#3), Let Me In (#6) |
| 5 | January 30, 2011 | $1,724,566 | Season of the Witch (#2), Burlesque (#5) |
| 6 | February 6, 2011 | Yogi Bear | $2,852,035 | Julia's Eyes (#2), True Grit (#7) |
| 7 | February 13, 2011 | $1,886,589 | Just Go with It (#2), Black Swan (#3), The Fighter (#7), Sin Memoria (#10) |
| 8 | February 20, 2011 | The Rite | $2,971,175 | Presumed Guilty (#5), The King's Speech (#6) |
| 9 | February 27, 2011 | $1,974,676 | Big Mommas: Like Father, Like Son (#2), Sanctum (#4), No Strings Attached (#6), 127 Hours (#10) |
| 10 | March 6, 2011 | Rango | $2,637,913 | I Am Number Four (#5) |
| 11 | March 13, 2011 | $2,164,257 | Battle: Los Angeles (#3) |
| 12 | March 20, 2011 | $1,296,512 | Mars Needs Moms (#2), Unknown (#3), Saving Private Perez (#4) |
| 13 | March 27, 2011 | Gnomeo & Juliet | $1,316,539 | La Otra Familia (#4), Sucker Punch (#7), Justin Bieber: Never Say Never (#8) |
| 14 | April 3, 2011 | $1,195,782 | The Adjustment Bureau (#3), Drive Angry (#9) |
| 15 | April 10, 2011 | Rio | $5,149,221 | |
| 16 | April 17, 2011 | $4,024,696 | Hop (#2), Scream 4 (#3), Hall Pass (#4) |
| 17 | April 24, 2011 | $3,069,573 | Red Riding Hood (#2), Limitless (#4) |
| 18 | May 1, 2011 | Thor | $7,201,607 | Water for Elephants (#4) |
| 19 | May 8, 2011 | Fast & Furious 5 | $7,148,381 | Garfield's Pet Force (#8) |
| 20 | May 15, 2011 | $4,852,120 | Priest (#3), The Lincoln Lawyer (#5) |
| 21 | May 22, 2011 | Pirates of the Caribbean: On Stranger Tides | $9,912,317 | Barney's Version (#9) |
| 22 | May 29, 2011 | $5,569,835 | The Hangover Part II (#2), Hoodwinked Too! Hood vs. Evil (#4) |
| 23 | June 5, 2011 | X-Men: First Class | $4,740,081 | All Good Things (#7) |
| 24 | June 12, 2011 | Kung Fu Panda 2 | $7,487,603 | Source Code (#5), Sexo, Amor y Otras Perversiones 2 (#8) |
| 25 | June 19, 2011 | $5,092,135 | Insidious (#4), The Beaver (#7), The Eagle (#9) |
| 26 | June 26, 2011 | Cars 2 | $8,242,857 | The Dilemma (#5) |
| 27 | July 3, 2011 | Transformers: Dark of the Moon | $10,197,801 | Something Borrowed (#4) |
| 28 | July 10, 2011 | $4,785,907 | Zookeeper (#3), Paranormal Activity 2: Tokyo Night (#6), Rabbit Hole (#9) |
| 29 | July 17, 2011 | Harry Potter and the Deathly Hallows – Part 2 | $15,863,441 | |
| 29 | July 24, 2011 | $4,973,685 | Mr. Popper's Penguins (#2), Bad Teacher (#5) |
| 30 | July 31, 2011 | Captain America: The First Avenger | $8,089,424 | Monte Carlo (#6) |
| 31 | August 7, 2011 | The Smurfs | $3,612,267 | Super 8 (#3), Horrible Bosses (#4), Midnight in Paris (#7) |
| 32 | August 14, 2011 | Green Lantern | $4,647,930 | The Lion King 3D (#5) |
| 33 | August 21, 2011 | $2,487,153 | Crazy, Stupid, Love (#3), The Possession of Emma Evans (#10) |
| 34 | August 28, 2011 | Cowboys & Aliens | $1,916,130 | Aphrodite Les Folies – Live in London (#10) |
| 35 | September 4, 2011 | Rise of the Planet of the Apes | $4,235,071 | Larry Crowne (#5), Beastly (#8), Paul (#9) |
| 36 | September 11, 2011 | $2,528,841 | Fright Night (#2), Conan the Barbarian (#4), Bridesmaids (#6), The Resident (#10) |
| 37 | September 18, 2011 | Don Gato y su Pandilla | $3,342,039 | Friends with Benefits (#3), Don't Be Afraid of the Dark (#4) |
| 38 | September 25, 2011 | $1,805,665 | The Change-Up (#2), Final Destination 5 (#4), Hierro (#8) |
| 39 | October 2, 2011 | Abduction | $1,219,931 | What's Your Number? (#5), Viento en Contra (#9) |
| 40 | October 9, 2011 | Real Steel | $2,991,326 | Labios Rojos (#4), I Don't Know How She Does It (#5) |
| 41 | October 16, 2011 | $2,589,059 | Dream House (#2), Moneyball (#3), The Greatest Miracle (#5), Killer Elite (#6) |
| 42 | October 23, 2011 | Paranormal Activity 3 | $1,919,043 | Johnny English Reborn (#3), La Leyenda de la Llorona (#4), The Tree of Life (#8) |
| 43 | October 30, 2011 | $1,473,570 | The Three Musketeers (#4), Contagion (#5) |
| 44 | November 6, 2011 | $944,666 | In Time (#2), Dolphin Tale (#6), Monsters (#10) |
| 45 | November 13, 2011 | Jack & Jill | $2,644,398 | Pastorela (#2), The Debt (#10) |
| 46 | November 20, 2011 | The Twilight Saga: Breaking Dawn – Part 1 | $6,699,100 | Happy Feet Two (#2) |
| 47 | November 27, 2011 | $2,744,130 | The Muppets (#2), The Thing (#7), Warrior (#8) |
| 48 | December 4, 2011 | Puss in Boots | $3,675,962 | The Skin I Live In (#7) |
| 49 | December 11, 2011 | $2,485,977 | Arthur Christmas (#3), Tower Heist (#4), 11-11-11 (#9) |
| 50 | December 18, 2011 | Alvin and the Chipmunks 3 | $1,518,400 | Immortals (#3), New Year's Eve (#4), Sleep Tight (#8) |
| 51 | December 25, 2011 | Mission: Impossible – Ghost Protocol | $1,967,186 | We Bought a Zoo (#8) |
| 52 | January 1, 2012 | Sherlock Holmes: A Game of Shadows | $2,023,876 | The Adventures of Tintin: The Secret of the Unicorn (#3), A Little Bit of Heaven (#8) |
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