Protein-coding gene in the species Homo sapiens
Mediator of RNA polymerase II transcription subunit 6 is one of the subunits of the Mediator complex . It is an enzyme that in humans is encoded by the MED6 gene .[ 5] [ 6] [ 7]
This family of proteins represent the transcriptional mediator protein subunit 6 that is required for activation of many RNA polymerase II promoters and which are conserved from yeast to humans .[ 5]
MED6 has been shown to interact with:
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"Antigens recognized by autologous antibody in patients with renal-cell carcinoma" . Int. J. Cancer . 83 (4): 456–464. doi :10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5 . PMID 10508479 . Ge K, Guermah M, Yuan CX, Ito M, Wallberg AE, Spiegelman BM, Roeder RG (2002). "Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis". Nature . 417 (6888): 563–567. Bibcode :2002Natur.417..563G . doi :10.1038/417563a . PMID 12037571 . S2CID 4432077 . Kato Y, Habas R, Katsuyama Y, Näär AM, He X (2002). "A component of the ARC/Mediator complex required for TGF beta/Nodal signalling". Nature . 418 (6898): 641–646. Bibcode :2002Natur.418..641K . doi :10.1038/nature00969 . PMID 12167862 . S2CID 4330754 . Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3" . 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