Melarsomine

Melarsomine
Clinical data
Trade names	Immiticide, Diroban
AHFS/Drugs.com	International Drug Names
ATC code	none;
Identifiers
	IUPAC name Bis(2-aminoethyl) {4-[(4,6-diamino-1,3,5-triazin-2-yl)amino]phenyl}arsonodithioite;
CAS Number	128470-15-5;
PubChem CID	65962;
ChemSpider	59365;
UNII	374GJ0S41A;
KEGG	D08168 ;
CompTox Dashboard (EPA)	DTXSID40155907 ;
Chemical and physical data
Formula	C13H21AsN8S2
Molar mass	428.41 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC(=CC=C1NC2=NC(=NC(=N2)N)N)[As](SCCN)SCCN;
	InChI InChI=1S/C13H21AsN8S2/c15-5-7-23-14(24-8-6-16)9-1-3-10(4-2-9)19-13-21-11(17)20-12(18)22-13/h1-4H,5-8,15-16H2,(H5,17,18,19,20,21,22); Key:MGEOLZFMLHYCFZ-UHFFFAOYSA-N;
	(verify)

Melarsomine (melaminylthioarsenate) is an arsenic-based anthelmintic. In the U.S., it is marketed under the trade names Immiticide (Merial) and Diroban (Zoetis), and is approved by the FDA's Center for Veterinary Medicine for the treatment of adult heartworm (Dirofilaria immitis) infection in dogs. It is not approved for treatment in cats, or dogs in late-stage infection.^[1]^[2]

References

^ Tilley LP (2008). Manual of Canine and Feline Cardiology. Elsevier Health Sciences. pp. 194–197. ISBN 978-1-4160-2398-2.
^ Bonagura JD, Twedt DC (2013). Kirk's Current Veterinary Therapy XV. Elsevier Health Sciences. p. 2502. ISBN 978-0-323-22762-9.

External links

American Heartworm Society

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[Tilley2008-1] Tilley LP (2008). Manual of Canine and Feline Cardiology. Elsevier Health Sciences. pp. 194–197. ISBN 978-1-4160-2398-2.

[BonaguraTwedt2013-2] Bonagura JD, Twedt DC (2013). Kirk's Current Veterinary Therapy XV. Elsevier Health Sciences. p. 2502. ISBN 978-0-323-22762-9.

[1]

[2]