NCOA4

NCOA4
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesNCOA4, ARA70, ELE1, PTC3, RFG, nuclear receptor coactivator 4
External IDsOMIM: 601984; MGI: 1350932; HomoloGene: 38052; GeneCards: NCOA4; OMA:NCOA4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

8031

27057

Ensembl

ENSG00000266412

ENSMUSG00000056234

UniProt

Q13772

n/a

RefSeq (mRNA)

NM_005437
NM_001145260
NM_001145261
NM_001145262
NM_001145263

NM_001033988
NM_001284319
NM_019744

RefSeq (protein)

NP_001138732
NP_001138733
NP_001138734
NP_001138735
NP_005428

n/a

Location (UCSC)Chr 10: 46.01 – 46.03 MbChr 14: 31.88 – 31.9 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nuclear receptor coactivator 4, also known as Androgen Receptor Activator (ARA70), is a protein that in humans is encoded by the NCOA4 gene.[5][6][7] It plays an important role in ferritinophagy, acting as a cargo receptor, binding to the ferritin heavy chain and latching on to ATG8 on the surface of the autophagosome.

Interactions

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NCOA4 has been shown to interact with:

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000266412 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056234 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Santoro M, Dathan NA, Berlingieri MT, Bongarzone I, Paulin C, Grieco M, Pierotti MA, Vecchio G, Fusco A (February 1994). "Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma". Oncogene. 9 (2): 509–16. PMID 8290261.
  6. ^ a b Yeh S, Chang C (May 1996). "Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells". Proceedings of the National Academy of Sciences of the United States of America. 93 (11): 5517–21. Bibcode:1996PNAS...93.5517Y. doi:10.1073/pnas.93.11.5517. PMC 39278. PMID 8643607.
  7. ^ "Entrez Gene: NCOA4 Nuclear receptor coactivator 4".
  8. ^ Alen P, Claessens F, Schoenmakers E, Swinnen JV, Verhoeven G, Rombauts W, Peeters B (January 1999). "Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform". Molecular Endocrinology. 13 (1): 117–28. doi:10.1210/mend.13.1.0214. PMID 9892017.
  9. ^ Miyamoto H, Yeh S, Wilding G, Chang C (June 1998). "Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells". Proceedings of the National Academy of Sciences of the United States of America. 95 (13): 7379–84. Bibcode:1998PNAS...95.7379M. doi:10.1073/pnas.95.13.7379. PMC 22623. PMID 9636157.
  10. ^ Lin HK, Yeh S, Kang HY, Chang C (June 2001). "Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor". Proceedings of the National Academy of Sciences of the United States of America. 98 (13): 7200–5. Bibcode:2001PNAS...98.7200L. doi:10.1073/pnas.121173298. PMC 34646. PMID 11404460.
  11. ^ Yeh S, Lin HK, Kang HY, Thin TH, Lin MF, Chang C (May 1999). "From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells". Proceedings of the National Academy of Sciences of the United States of America. 96 (10): 5458–63. Bibcode:1999PNAS...96.5458Y. doi:10.1073/pnas.96.10.5458. PMC 21881. PMID 10318905.
  12. ^ Zhou ZX, He B, Hall SH, Wilson EM, French FS (February 2002). "Domain interactions between coregulator ARA(70) and the androgen receptor (AR)". Molecular Endocrinology. 16 (2): 287–300. doi:10.1210/mend.16.2.0765. PMID 11818501.
  13. ^ He B, Minges JT, Lee LW, Wilson EM (March 2002). "The FXXLF motif mediates androgen receptor-specific interactions with coregulators". The Journal of Biological Chemistry. 277 (12): 10226–35. doi:10.1074/jbc.M111975200. PMID 11779876.
  14. ^ Gao T, Brantley K, Bolu E, McPhaul MJ (October 1999). "RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays". Molecular Endocrinology. 13 (10): 1645–56. doi:10.1210/mend.13.10.0352. PMID 10517667.
  15. ^ He B, Wilson EM (March 2003). "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Molecular and Cellular Biology. 23 (6): 2135–50. doi:10.1128/mcb.23.6.2135-2150.2003. PMC 149467. PMID 12612084.
  16. ^ Heinlein CA, Ting HJ, Yeh S, Chang C (June 1999). "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma". The Journal of Biological Chemistry. 274 (23): 16147–52. doi:10.1074/jbc.274.23.16147. PMID 10347167.
  17. ^ Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC (May 2014). "Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy" (PDF). Nature. 509 (7498): 105–9. Bibcode:2014Natur.509..105M. doi:10.1038/nature13148. PMC 4180099. PMID 24695223.
  18. ^ Dowdle WE, Nyfeler B, Nagel J, Elling RA, Liu S, Triantafellow E, et al. (November 2014). "Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo". Nature Cell Biology. 16 (11): 1069–79. doi:10.1038/ncb3053. PMID 25327288. S2CID 21172670.
  19. ^ Bellelli R, Federico G, Matte' A, Colecchia D, Iolascon A, Chiariello M, Santoro M, De Franceschi L, Carlomagno F (January 2016). "NCOA4 Deficiency Impairs Systemic Iron Homeostasis". Cell Reports. 14 (3): 411–421. doi:10.1016/j.celrep.2015.12.065. PMID 26776506.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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