NUDT6

NUDT6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNUDT6, ASFGF2, FGF-AS, FGF2AS, GFG-1, GFG1, nudix hydrolase 6
External IDsOMIM: 606261; MGI: 2387618; HomoloGene: 31425; GeneCards: NUDT6; OMA:NUDT6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_198041
NM_007083

NM_001291044
NM_153561

RefSeq (protein)

NP_009014
NP_932158

NP_001277973
NP_705789

Location (UCSC)Chr 4: 122.89 – 122.92 MbChr 3: 37.46 – 37.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleoside diphosphate-linked moiety X motif 6 is a protein that in humans is encoded by the NUDT6 gene.[5][6][7]

FGF2 (MIM 134920) is a highly conserved, multifunctional heparin-binding growth factor involved in neuroectoderm development, angiogenesis, and wound healing.

Elevated levels of FGF2 are associated with proliferation of smooth muscle in atherosclerosis and with proliferation of tumors. The FGF2 antisense gene, NUDT6, may regulate FGF2 expression.[supplied by OMIM][7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170917Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050174Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Murphy PR, Knee RS (Jan 1995). "Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene". Mol Endocrinol. 8 (7): 852–9. doi:10.1210/mend.8.7.7984147. PMID 7984147.
  6. ^ Gagnon ML, Moy GK, Klagsbrun M (Apr 1999). "Characterization of the promoter for the human antisense fibroblast growth factor-2 gene; regulation by Ets in Jurkat T cells". J Cell Biochem. 72 (4): 492–506. doi:10.1002/(SICI)1097-4644(19990315)72:4<492::AID-JCB5>3.0.CO;2-H. PMID 10022609. S2CID 28384265.
  7. ^ a b "Entrez Gene: NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6".

Further reading

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