Nafadotride
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Names | |
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IUPAC name N-{[(2S)-1-butylpyrrolidin-2-yl]methyl}-4-cyano-1-methoxy-2-naphthamide | |
Identifiers | |
3D model (JSmol) | |
ChEMBL | |
MeSH | Nafadotride |
PubChem CID | |
UNII | |
CompTox Dashboard (EPA) | |
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Properties | |
C22H27N3O2 | |
Molar mass | 365.477 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). |
Nafadotride is a dopamine antagonist with reasonable selectivity for the D3 subtype (9.6 times selectivity for D3 over D2).[1]
References
[edit]- ^ Pilla M, Perachon S, Sautel F, Garrido F, Mann A, Wermuth CG, Schwartz JC, Everitt BJ, Sokoloff P. Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 agonist. Nature. 1999;400:371–375.